Mild, Fast, and Easy To Conduct MoCl5‑Mediated Dehydrogenative Coupling Reactions in Flow

A convenient and straightforward approach to performing oxidative coupling reactions in flow is presented. A collection of electron-rich benzene derivatives was subjected to this protocol, and the distinct utility of molybdenum pentachloride (MoCl5) is established. Using this unexplored protocol, bi...

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Bibliographic Details
Published inOrganic letters Vol. 20; no. 13; pp. 4107 - 4110
Main Authors Beil, Sebastian B, Uecker, Ise, Franzmann, Peter, Müller, Timo, Waldvogel, Siegfried R
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 06.07.2018
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
DDQ
TRANSFORMATION
ORGANIC-SYNTHESIS
MECHANISM
DEHYDRODIMERIZATION
AROMATIC-COMPOUNDS
EFFICIENT
DERIVATIVES
SCHOLL REACTION
MOLYBDENUM PENTACHLORIDE
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Summary:A convenient and straightforward approach to performing oxidative coupling reactions in flow is presented. A collection of electron-rich benzene derivatives was subjected to this protocol, and the distinct utility of molybdenum pentachloride (MoCl5) is established. Using this unexplored protocol, biphenyls could be obtained in 21–91% isolated yield. This simple protocol opens a new chapter in reagent-mediated dehydrogenative coupling reactions, and yields are compared to classical approaches.
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ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.8b01664