Gemini Surfactant-Induced Cysteine-Capped Copper Nanoclusters Self-Assembly with Enhanced Peroxidase-Like Activity and Colorimetric Glutathione Sensing

We have prepared a novel assembly with copper nanoclusters (CuNCs) and imidazolium-based gemini surfactants (different chain lengths). These novel mimic enzymes formed through the assembly of nanocluster-gemini surfactants have been utilized in creating colorimetric sensors to detect biomolecules. Y...

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Bibliographic Details
Published inLangmuir Vol. 40; no. 32; pp. 16909 - 16920
Main Authors Shaheen, Arifa, Dhanagar, Arun
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 13.08.2024
Subjects
Colorimetry - methods
Copper - chemistry
Cysteine - analysis
Cysteine - chemistry
Glutathione - analysis
Glutathione - chemistry
Imidazoles - chemistry
Metal Nanoparticles - chemistry
Peroxidase - chemistry
Peroxidase - metabolism
Surface-Active Agents - chemistry
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Summary:We have prepared a novel assembly with copper nanoclusters (CuNCs) and imidazolium-based gemini surfactants (different chain lengths). These novel mimic enzymes formed through the assembly of nanocluster-gemini surfactants have been utilized in creating colorimetric sensors to detect biomolecules. Yet, understanding the method for detecting glutathione (GSH) and its sensing mechanism using this specific assembly-based colorimetric sensor poses a significant challenge. Because of the role of surface ligands, the complexes of cysteine-capped CuNCs (Cys-CuNCs) and gemini surfactants exhibit strong amphiphilicity, enabling them to self-assemble like a molecular amphiphile. We have investigated the kinetics and catalytic capabilities of this Cys-CuNCs@gemini surfactant assembly through peroxidase-like activity. Additionally, a sensitive and simple-to-use colorimetric sensing approach for glutathione (GSH) is also disclosed here, demonstrating a low limit of detection, by using this peroxidase-like activity of Cys-CuNCs@gemini surfactant assemblies. Thus, the remarkable advantages of the Cys-CuNCs@gemini surfactant nanozyme make it suitable for the precise colorimetric detection of GSH, demonstrating excellent sensitivity and reliable selectivity. Additionally, it performs well in detecting GSH in various soft drinks.
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ISSN:0743-7463
1520-5827
1520-5827
DOI:10.1021/acs.langmuir.4c01620