Spicy Recipe for At-Home Diagnostics: Smart Salivary Sensors for Point-of-Care Diagnosis of Jaundice

Even though significant advances have been made, there is still a lack of reliable sensors capable of noninvasively monitoring bilirubin and diagnosing jaundice as the most common neonatal disease, particularly at the point-of-care (POC) where blood sampling from infants is accompanied by serious ch...

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Bibliographic Details
Published inACS sensors Vol. 9; no. 6; pp. 3455 - 3464
Main Authors Golmohammadi, Hamed, Parnianchi, Fatemeh, Sharifi, Amir Reza, Naghdi, Tina, Tabatabaee, Raziyeh Sadat, Peyravian, Mohammad, Kashanian, Soheila
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 28.06.2024
Subjects
Bilirubin - analysis
Bilirubin - blood
Biosensing Techniques - instrumentation
Biosensing Techniques - methods
Curcumin - chemistry
Humans
Infant
Infant, Newborn
Jaundice - blood
Jaundice - diagnosis
Point-of-Care Systems
Saliva - chemistry
bilirubin
saliva sensors
noninvasive diagnostics
jaundice
optical sensors
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Summary:Even though significant advances have been made, there is still a lack of reliable sensors capable of noninvasively monitoring bilirubin and diagnosing jaundice as the most common neonatal disease, particularly at the point-of-care (POC) where blood sampling from infants is accompanied by serious challenges and concerns. Herein, for the first time, using an easy-to-fabricate/use assay, we demonstrate the capability of curcumin embedded within paper for noninvasive optical monitoring of bilirubin in saliva. The highly selective sensing of the developed sensor toward bilirubin is attributed to bilirubin photoisomerization under blue light exposure, which can selectively restore the bilirubin-induced quenched fluorescence of curcumin. We also fabricated an IoT-enabled hand-held optoelectronic reader to measure and quantify the fluorescence and color signals of our sensor. Clinical analysis on the saliva of 18 jaundiced infants by using our developed smart salivary sensor proved that it is amenable to be widely exploited in POC applications for bilirubin monitoring as there are good correlations between its results with those of reference methods in saliva and blood. Meeting all WHO’s REASSURED criteria by our developed sensor makes it a highly promising sensor for smart noninvasive diagnosis and therapeutic monitoring of jaundice, hepatitis, and other bilirubin-induced neurologic diseases at the POC.
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ISSN:2379-3694
2379-3694
DOI:10.1021/acssensors.4c01066