I2/TBHP-Catalyzed Chemoselective Amination of Indoles

A novel I2/TBHP-mediated direct oxidative diamination reaction of indoles with anilines was developed. The reaction proceeded smoothly under aqueous and open air reaction conditions. This protocol provides a practical synthetic method for the synthesis of Tryptanthrin and the construction of N–C3 li...

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Bibliographic Details
Published inOrganic letters Vol. 15; no. 20; pp. 5226 - 5229
Main Authors Cai, Zhong-Jian, Wang, Shun-Yi, Ji, Shun-Jun
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 18.10.2013
Subjects
Amination
Amines - chemical synthesis
Amines - chemistry
Catalysis
Crystallography, X-Ray
Indoles - chemistry
Iodine - chemistry
Models, Molecular
Molecular Structure
tert-Butylhydroperoxide - chemistry
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Summary:A novel I2/TBHP-mediated direct oxidative diamination reaction of indoles with anilines was developed. The reaction proceeded smoothly under aqueous and open air reaction conditions. This protocol provides a practical synthetic method for the synthesis of Tryptanthrin and the construction of N–C3 linked pyrrolidinoindolines which is the core structure of Psychotrimine.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1523-7060
1523-7052
DOI:10.1021/ol4023936