Production of 230U/226Th for Targeted Alpha Therapy via Proton Irradiation of 231Pa
230U and its daughter nuclide 226Th are novel therapeutic nuclides for application in targeted α-therapy of cancer. We have investigated the feasibility of producing 230U/226Th via proton irradiation of 231Pa according to the reaction 231Pa(p,2n)230U. The experimental excitation function for this re...
Saved in:
Published in | Analytical chemistry (Washington) Vol. 80; no. 22; pp. 8763 - 8770 |
---|---|
Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Washington, DC
American Chemical Society
15.11.2008
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | 230U and its daughter nuclide 226Th are novel therapeutic nuclides for application in targeted α-therapy of cancer. We have investigated the feasibility of producing 230U/226Th via proton irradiation of 231Pa according to the reaction 231Pa(p,2n)230U. The experimental excitation function for this reaction is reported for the first time. Cross sections were measured using thin targets of 231Pa prepared by electrodeposition and 230U yields were analyzed using α-spectrometry. Beam parameters (energy and intensity) were determined both by calculation using a mathematical model based on measured beam orbits and beam current integrator and by parallel monitor reactions on copper foils using high-resolution γ-spectrometry and IAEA recommended cross-section data. The measured cross sections are in good agreement with model calculations using the EMPIRE-II code and are sufficiently high for the production of 230U/226Th in clinically relevant amounts. A highly effective separation process was developed to isolate clinical grade 230U from irradiated protactinium oxide targets. Product purity was assessed using α- and γ-spectrometry as well as ICPMS. |
---|---|
Bibliography: | istex:A23C88B05C200B5416ED5BF96F094650BF1135B6 ark:/67375/TPS-ML914TP3-X Additional information as noted in text. This material is available free of charge via the Internet at http://pubs.acs.org. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0003-2700 1520-6882 |
DOI: | 10.1021/ac801304c |