Lignin/Surfactin Coacervate as an Eco-Friendly Pesticide Carrier and Antifungal Agent against Phytopathogen

• Published in: ACS nano Vol. 18; no. 33; pp. 22415 - 22430
• Main Authors: Wang, Jie, Xiong, Zhichen, Fan, Yaxun, Wang, Hongliang, An, Changcheng, Wang, Bo, Yang, Ming, Li, Xue, Wang, Yan, Wang, Yilin
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 20.08.2024
• Subjects: Antifungal Agents - chemistry; Antifungal Agents - pharmacology; Drug Carriers - chemistry; Fungicides, Industrial - chemistry; Fungicides, Industrial - pharmacology; Lignin - chemistry; Lignin - pharmacology; Lipopeptides - chemistry; Lipopeptides - pharmacology; Microbial Sensitivity Tests; Particle Size; Pesticides - chemistry; Pesticides - pharmacology; Solanum lycopersicum - drug effects; Solanum lycopersicum - microbiology; Strobilurins - chemistry; Strobilurins - pharmacology; biomass; carrier; coacervate; fungicide; biosurfactant
• ISSN: 1936-0851; 1936-086X; 1936-086X
• DOI: 10.1021/acsnano.4c07173

Excessive usage of biologically toxic fungicides and their matrix materials poses a serious threat to public health. Leveraging fungicide carriers with inherent pathogen inhibition properties is highly promising for enhancing fungicide efficacy and reducing required dosage. Herein, a series of coacervates have been crafted with lignin and surfactin, both of which are naturally derived and demonstrate substantial antifungal properties. This hierarchically assembled carrier not only effectively loads fungicides with a maximum encapsulation efficiency of 95% but also stably deposits on hydrophobic leaves for high-speed impacting droplets. Intriguingly, these coacervates exhibit broad spectrum fungicidal activity against eight ubiquitous phytopathogens and even act as a standalone biofungicide to replace fungicides. This performance can significantly reduce the fungicide usage and be further strengthened by an encapsulated fungicide. The inhibition rate reaches 87.0% when 0.30 mM pyraclostrobin (Pyr) is encapsulated within this coacervate, comparable to the effectiveness of 0.80 mM Pyr alone. Additionally, the preventive effects against tomato gray mold reached 53%, significantly surpassing those of commercial adjuvants. Thus, it demonstrates that utilizing biosurfactants and biomass with intrinsic antifungal activity to fabricate fully biobased coacervates can synergistically combine the functions of a fungicide carrier and antifungal agent against phytopathogens and guarantee environmental friendliness. This pioneering approach provides deeper insights into synergistically enhancing the effectiveness of agrochemicals from multiple aspects, including fungicide encapsulation, cooperative antifungal action, and droplet deposition.