Preparation of Difluoromethylated Benzothiophene by Visible-Light-Mediated Alkyne Difunctionalization Reaction

An efficient method for the preparation of difluoromethylated benzothiophenes via visible-light-mediated alkyne difunctionalization was developed. In this method, inexpensive sodium difluoromethanesulfinate (HCF2SO2Na) was used as the fluorine source, and a variety of benzothiophene derivatives were...

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Published inJournal of organic chemistry Vol. 89; no. 18; pp. 13367 - 13372
Main Authors Zhang, Dong, Sun, Yu, Wang, Ganwen, Liu, Ying, Ni, Chunjie, Ji, Qingzhi, Xu, Xiaojuan, Fang, Zheng
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 20.09.2024
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Summary:An efficient method for the preparation of difluoromethylated benzothiophenes via visible-light-mediated alkyne difunctionalization was developed. In this method, inexpensive sodium difluoromethanesulfinate (HCF2SO2Na) was used as the fluorine source, and a variety of benzothiophene derivatives were obtained in moderate to excellent yield under mild reaction conditions. Moreover, the reaction operation is simple and easy to scale up.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0022-3263
1520-6904
1520-6904
DOI:10.1021/acs.joc.4c01528