Application of In Situ Mucoadhesive Hydrogel with Anti-Inflammatory and Pro-Repairing Dual Properties for the Treatment of Chemotherapy-Induced Oral Mucositis

• Published in: ACS applied materials & interfaces Vol. 16; no. 28; pp. 35949 - 35963
• Main Authors: Kang, Yujie, Xiong, Yahui, Lu, Bingxu, Wang, Yunyi, Zhang, Danya, Feng, Jinghao, Chen, Lei, Zhang, Zhaoqiang
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 17.07.2024
• Subjects: Alginates - chemistry; Animals; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Biological and Medical Applications of Materials and Interfaces; Catechin - analogs & derivatives; Catechin - chemistry; Catechin - pharmacology; Catechin - therapeutic use; Dopamine - chemistry; Dopamine - pharmacology; Humans; Hyaluronic Acid - chemistry; Hyaluronic Acid - pharmacology; Hydrogels - chemistry; Hydrogels - pharmacology; Keratinocytes - drug effects; Methacrylates - chemistry; Mice; Stomatitis - chemically induced; Stomatitis - drug therapy; Stomatitis - pathology; Wound Healing - drug effects; anti-inflammatory; treatment; pro-restoration; chemotherapy-induced oral mucositis; hydrogel
• ISSN: 1944-8244; 1944-8252; 1944-8252
• DOI: 10.1021/acsami.4c03217

Chemotherapy-induced oral mucositis (CIOM) is a prevalent complication of chemotherapy and significantly affects the treatment process. However, effective treatment for CIOM is lacking due to the unique environment of the oral cavity and the single effect of current drug delivery systems. In this present study, we propose an innovative approach by combining a methacrylate-modified human recombinant collagen III (rhCol3MA) hydrogel system with hyaluronic acid-epigallocatechin gallate (HA-E) and dopamine-modified methacrylate-alginate (AlgDA-MA). HA-E is used as an antioxidant and anti-inflammatory agent and synergizes with AlgDA-MA to improve the wet adhesion of hydrogel. The results of rhCol3MA/HA-E/AlgDA-MA (Col/HA-E/Alg) hydrogel demonstrate suitable physicochemical properties, excellent wet adhesive capacity, and biocompatibility. Notably, the hydrogel could promote macrophage polarization from M1 to M2 and redress human oral keratinocyte (HOK) inflammation by inhibiting NF-κB activation. Wound healing evaluations in vivo demonstrate that the Col/HA-E/Alg hydrogel exhibits a pro-repair effect by mitigating inflammatory imbalances, fostering early angiogenesis, and facilitating collagen repair. In summary, the Col/HA-E/Alg hydrogel could serve as a promising multifunctional dressing for the treatment of CIOM.