Use of frozen native feces for fecal microbiota transplantation in recurrent Clostridioides difficile infection: a simple way to improve the efficiency of donor feces preparation

• Published in: Antimicrobial agents and chemotherapy Vol. 68; no. 10; p. e0073424
• Main Authors: Sintes, Rachel, McLellan, Paul, Navelli, Gabriele, Landman, Cécilia, Delage, Sandrine, Truong, Sandrine, Benech, Nicolas, Kapel, Nathalie, Moreino Sabater, Alicia, Schnuriger, Aurélie, Eckert, Catherine, Bleibtreu, Alexandre, Joly, Anne-Christine, Sokol, Harry
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 08.10.2024
• Subjects: Adult; Aged; Clinical Therapeutics; Clostridioides difficile; Clostridium Infections - microbiology; Clostridium Infections - therapy; Editor’s Pick; Fecal Microbiota Transplantation - methods; Feces - microbiology; Female; Freezing; Human Microbiome; Humans; Male; Middle Aged; Recurrence; Retrospective Studies; FMT; fecal microbiota transplantation; Clostridium difficile

Preparing fecal microbiota transplants immediately after donation is resource-intensive, and a proportion are destroyed following abnormal screening results. We retrospectively compared two processes, frozen fecal preparation (FFP) and fresh native frozen preparation (FNFP), for clinical efficacy in...