Use of frozen native feces for fecal microbiota transplantation in recurrent Clostridioides difficile infection: a simple way to improve the efficiency of donor feces preparation

Preparing fecal microbiota transplants immediately after donation is resource-intensive, and a proportion are destroyed following abnormal screening results. We retrospectively compared two processes, frozen fecal preparation (FFP) and fresh native frozen preparation (FNFP), for clinical efficacy in...

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Published inAntimicrobial agents and chemotherapy Vol. 68; no. 10; p. e0073424
Main Authors Sintes, Rachel, McLellan, Paul, Navelli, Gabriele, Landman, Cécilia, Delage, Sandrine, Truong, Sandrine, Benech, Nicolas, Kapel, Nathalie, Moreino Sabater, Alicia, Schnuriger, Aurélie, Eckert, Catherine, Bleibtreu, Alexandre, Joly, Anne-Christine, Sokol, Harry
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 08.10.2024
Subjects
Adult
Aged
Clinical Therapeutics
Clostridioides difficile
Clostridium Infections - microbiology
Clostridium Infections - therapy
Editor’s Pick
Fecal Microbiota Transplantation - methods
Feces - microbiology
Female
Freezing
Human Microbiome
Humans
Male
Middle Aged
Recurrence
Retrospective Studies
FMT
fecal microbiota transplantation
Clostridium difficile
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Summary:Preparing fecal microbiota transplants immediately after donation is resource-intensive, and a proportion are destroyed following abnormal screening results. We retrospectively compared two processes, frozen fecal preparation (FFP) and fresh native frozen preparation (FNFP), for clinical efficacy in the treatment of recurrent infection (rCDI). FFP and FNFP were similarly effective with clinical success rates of 76.7% and 86.7% ( = 0.32), respectively. FNFP is an efficient procedure that saves resources while maintaining clinical efficacy in rCDI.
Bibliography:ObjectType-Article-1
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content type line 23
ISSN:0066-4804
1098-6596
1098-6596
DOI:10.1128/aac.00734-24