Use of frozen native feces for fecal microbiota transplantation in recurrent Clostridioides difficile infection: a simple way to improve the efficiency of donor feces preparation

Preparing fecal microbiota transplants immediately after donation is resource-intensive, and a proportion are destroyed following abnormal screening results. We retrospectively compared two processes, frozen fecal preparation (FFP) and fresh native frozen preparation (FNFP), for clinical efficacy in...

Full description

Saved in:
Bibliographic Details
Published inAntimicrobial agents and chemotherapy Vol. 68; no. 10; p. e0073424
Main Authors Sintes, Rachel, McLellan, Paul, Navelli, Gabriele, Landman, Cécilia, Delage, Sandrine, Truong, Sandrine, Benech, Nicolas, Kapel, Nathalie, Moreino Sabater, Alicia, Schnuriger, Aurélie, Eckert, Catherine, Bleibtreu, Alexandre, Joly, Anne-Christine, Sokol, Harry
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 08.10.2024
Subjects
Adult
Aged
Clinical Therapeutics
Clostridioides difficile
Clostridium Infections - microbiology
Clostridium Infections - therapy
Editor’s Pick
Fecal Microbiota Transplantation - methods
Feces - microbiology
Female
Freezing
Human Microbiome
Humans
Male
Middle Aged
Recurrence
Retrospective Studies
FMT
fecal microbiota transplantation
Clostridium difficile
Online AccessGet full text

Cover

Abstract Preparing fecal microbiota transplants immediately after donation is resource-intensive, and a proportion are destroyed following abnormal screening results. We retrospectively compared two processes, frozen fecal preparation (FFP) and fresh native frozen preparation (FNFP), for clinical efficacy in the treatment of recurrent infection (rCDI). FFP and FNFP were similarly effective with clinical success rates of 76.7% and 86.7% ( = 0.32), respectively. FNFP is an efficient procedure that saves resources while maintaining clinical efficacy in rCDI.
AbstractList Preparing fecal microbiota transplants immediately after donation is resource-intensive, and a proportion are destroyed following abnormal screening results. We retrospectively compared two processes, frozen fecal preparation (FFP) and fresh native frozen preparation (FNFP), for clinical efficacy in the treatment of recurrent Clostridioides difficile infection (rCDI). FFP and FNFP were similarly effective with clinical success rates of 76.7% and 86.7% (P = 0.32), respectively. FNFP is an efficient procedure that saves resources while maintaining clinical efficacy in rCDI.
ABSTRACT Preparing fecal microbiota transplants immediately after donation is resource-intensive, and a proportion are destroyed following abnormal screening results. We retrospectively compared two processes, frozen fecal preparation (FFP) and fresh native frozen preparation (FNFP), for clinical efficacy in the treatment of recurrent Clostridioides difficile infection (rCDI). FFP and FNFP were similarly effective with clinical success rates of 76.7% and 86.7% ( P = 0.32), respectively. FNFP is an efficient procedure that saves resources while maintaining clinical efficacy in rCDI.
Preparing fecal microbiota transplants immediately after donation is resource-intensive, and a proportion are destroyed following abnormal screening results. We retrospectively compared two processes, frozen fecal preparation (FFP) and fresh native frozen preparation (FNFP), for clinical efficacy in the treatment of recurrent Clostridioides difficile infection (rCDI). FFP and FNFP were similarly effective with clinical success rates of 76.7% and 86.7% (P = 0.32), respectively. FNFP is an efficient procedure that saves resources while maintaining clinical efficacy in rCDI.Preparing fecal microbiota transplants immediately after donation is resource-intensive, and a proportion are destroyed following abnormal screening results. We retrospectively compared two processes, frozen fecal preparation (FFP) and fresh native frozen preparation (FNFP), for clinical efficacy in the treatment of recurrent Clostridioides difficile infection (rCDI). FFP and FNFP were similarly effective with clinical success rates of 76.7% and 86.7% (P = 0.32), respectively. FNFP is an efficient procedure that saves resources while maintaining clinical efficacy in rCDI.
Preparing fecal microbiota transplants immediately after donation is resource-intensive, and a proportion are destroyed following abnormal screening results. We retrospectively compared two processes, frozen fecal preparation (FFP) and fresh native frozen preparation (FNFP), for clinical efficacy in the treatment of recurrent infection (rCDI). FFP and FNFP were similarly effective with clinical success rates of 76.7% and 86.7% ( = 0.32), respectively. FNFP is an efficient procedure that saves resources while maintaining clinical efficacy in rCDI.
Author Navelli, Gabriele
McLellan, Paul
Bleibtreu, Alexandre
Delage, Sandrine
Moreino Sabater, Alicia
Sokol, Harry
Joly, Anne-Christine
Schnuriger, Aurélie
Eckert, Catherine
Kapel, Nathalie
Sintes, Rachel
Landman, Cécilia
Truong, Sandrine
Benech, Nicolas
Author_xml – sequence: 1
  givenname: Rachel
  orcidid: 0009-0000-6205-3560
  surname: Sintes
  fullname: Sintes, Rachel
  organization: French Group for Fecal Microbiota Transplantation (GFTF), Paris, France
– sequence: 2
  givenname: Paul
  surname: McLellan
  fullname: McLellan, Paul
  organization: Department of Gastroenterology, Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Saint-Antoine Hospital, Paris, France
– sequence: 3
  givenname: Gabriele
  surname: Navelli
  fullname: Navelli, Gabriele
  organization: French Group for Fecal Microbiota Transplantation (GFTF), Paris, France
– sequence: 4
  givenname: Cécilia
  surname: Landman
  fullname: Landman, Cécilia
  organization: Department of Gastroenterology, Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Saint-Antoine Hospital, Paris, France
– sequence: 5
  givenname: Sandrine
  surname: Delage
  fullname: Delage, Sandrine
  organization: French Group for Fecal Microbiota Transplantation (GFTF), Paris, France
– sequence: 6
  givenname: Sandrine
  surname: Truong
  fullname: Truong, Sandrine
  organization: Department of Gastroenterology, Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Saint-Antoine Hospital, Paris, France
– sequence: 7
  givenname: Nicolas
  surname: Benech
  fullname: Benech, Nicolas
  organization: Department of Hepato-Gastroenterology, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France
– sequence: 8
  givenname: Nathalie
  surname: Kapel
  fullname: Kapel, Nathalie
  organization: Functional Coprology Laboratory, APHP, Pitié Salpêtrière Hospital and Université Paris Cité, INSERM UMRS-1139, Centre d'Immunologie et des Maladies Infectieuses, (CIMI-PARIS), Inserm U1135, Sorbonne Université, Paris, France
– sequence: 9
  givenname: Alicia
  surname: Moreino Sabater
  fullname: Moreino Sabater, Alicia
  organization: Sorbonne Université, APHP, National Institute of Health and Medical Research, Center for Immunology and Infectious Diseases-Paris, Saint Antoine Hospital, Parasitology-Mycology, Paris, France
– sequence: 10
  givenname: Aurélie
  orcidid: 0000-0003-0931-8720
  surname: Schnuriger
  fullname: Schnuriger, Aurélie
  organization: Sorbonne Université, AP-HP, Saint-Antoine Hospital, Virology, Paris, France
– sequence: 11
  givenname: Catherine
  surname: Eckert
  fullname: Eckert, Catherine
  organization: Sorbonne Université, AP-HP, Saint-Antoine Hospital, Bacteriology et Centre d'Immunologie et des Maladies Infectieuses, INSERM, U1135, Sorbonne Université, Paris, France
– sequence: 12
  givenname: Alexandre
  surname: Bleibtreu
  fullname: Bleibtreu, Alexandre
  organization: Department of Infectious Disease, Sorbonne Université, AP-HP, Pitié-Salpêtrière Hospital, Paris, France
– sequence: 13
  givenname: Anne-Christine
  surname: Joly
  fullname: Joly, Anne-Christine
  organization: French Group for Fecal Microbiota Transplantation (GFTF), Paris, France
– sequence: 14
  givenname: Harry
  orcidid: 0000-0002-2914-1822
  surname: Sokol
  fullname: Sokol, Harry
  organization: Université Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy-en-Josas, France
BackLink https://www.ncbi.nlm.nih.gov/pubmed/39166867$$D View this record in MEDLINE/PubMed
BookMark eNp1kU1v1DAQhi3Uim4LN87IR5BIsZ3YSbihFR-VKvVCz5bjjIWrxA62A1p-Fr-wk93CjZNnrGfeeWfmkpyFGICQV5xdcy6698bYa8bauqlE84zsOOu7SslenZEdY0pVTceaC3KZ8wPDXPbsObmoe65Up9od-XOfgUZHXYq_IdBgiv8J1IGFTF1MW2QmOnub4uBjMbQkE_IymVAQjYH6QBPYNSUIhe6nmEvyo49-RIHRO-etnwApFNr4D9TQ7OcF_36ZAy2RYpIi9izfgcKRh2APm6cxhpMDlFoSLCYdW74g585MGV4-vVfk_vOnb_uv1e3dl5v9x9vKCC5KNQytUs6CHJiUo2WWS9upAYYW6mG0km9RX4MyreilEm7kslFd2ynR4cpMfUXenHTR348VctGzzxYmnB3imnXNsKxVWIrouxOKa8o5gdNL8rNJB82Z3q6k8Ur6eCUtGsTfnnCTZ6Ef4poCDvI_9vWTi3WYYfwn_PeE9SN4raEC
Cites_doi 10.1038/nrgastro.2016.98
10.1684/hpg.2017.1438
10.1016/j.pharma.2015.02.004
10.1111/apt.13009
10.1016/j.eclinm.2020.100642
10.1038/s41575-020-0350-4
10.1186/s40168-022-01267-2
10.1038/ajg.2011.482
10.1038/s41598-019-45173-4
10.1111/apt.13366
10.1177/2050640618780762
10.1136/gutjnl-2019-319630
10.1016/j.dld.2015.08.017
10.1056/NEJMoa1205037
10.1093/cid/ciu135
10.1053/j.gastro.2016.11.010
10.1136/gutjnl-2019-319548
ContentType Journal Article
Copyright Copyright © 2024 American Society for Microbiology.
Copyright_xml – notice: Copyright © 2024 American Society for Microbiology.
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
DOI 10.1128/aac.00734-24
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
MEDLINE - Academic
DatabaseTitleList
CrossRef
MEDLINE - Academic
MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Biology
Pharmacy, Therapeutics, & Pharmacology
EISSN 1098-6596
Editor Silverman, Jared A.
Editor_xml – sequence: 1
  givenname: Jared A.
  surname: Silverman
  fullname: Silverman, Jared A.
ExternalDocumentID 10_1128_aac_00734_24
aac00734-24
39166867
Genre Journal Article
GrantInformation_xml – fundername: Société de Pathologie Infectieuse de Langue Francase
– fundername: Société Nationale Francaise de Gastro Enterologie
GroupedDBID ---
.55
0R~
23M
2WC
39C
4.4
53G
5GY
5RE
5VS
6J9
ACGFO
ADBBV
AENEX
AGVNZ
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BTFSW
CGR
CS3
CUY
CVF
DIK
E3Z
EBS
ECM
EIF
F5P
FRP
GX1
H13
HH5
HZ~
H~9
K-O
KQ8
L7B
LSO
NPM
O9-
OK1
P2P
RHF
RHI
RNS
RPM
RSF
TR2
UHB
W2D
WH7
WOQ
X7M
AAYXX
CITATION
7X8
ID FETCH-LOGICAL-a212t-bb766fce5b055dc0c15c86beb7e3bdc51eb7e93e6a729562fd1546878628804a3
ISSN 0066-4804
1098-6596
IngestDate Sat Oct 26 02:03:17 EDT 2024
Wed Oct 09 16:46:24 EDT 2024
Tue Oct 08 18:22:43 EDT 2024
Sat Nov 02 12:03:57 EDT 2024
IsPeerReviewed true
IsScholarly true
Issue 10
Keywords FMT
fecal microbiota transplantation
Clostridium difficile
Language English
License All Rights Reserved. https://doi.org/10.1128/ASMCopyrightv2
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-a212t-bb766fce5b055dc0c15c86beb7e3bdc51eb7e93e6a729562fd1546878628804a3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0002-2914-1822
0000-0003-0931-8720
0009-0000-6205-3560
PMID 39166867
PQID 3095676562
PQPubID 23479
PageCount 6
ParticipantIDs proquest_miscellaneous_3095676562
crossref_primary_10_1128_aac_00734_24
asm2_journals_10_1128_aac_00734_24
pubmed_primary_39166867
PublicationCentury 2000
PublicationDate 2024-Oct-08
PublicationDateYYYYMMDD 2024-10-08
PublicationDate_xml – month: 10
  year: 2024
  text: 2024-Oct-08
  day: 08
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: 1752 N St., N.W., Washington, DC
PublicationTitle Antimicrobial agents and chemotherapy
PublicationTitleAbbrev Antimicrob Agents Chemother
PublicationTitleAlternate Antimicrob Agents Chemother
PublicationYear 2024
Publisher American Society for Microbiology
Publisher_xml – name: American Society for Microbiology
References Khoruts, A, Sadowsky, MJ (B17) 2016; 13
Hamilton, MJ, Weingarden, AR, Sadowsky, MJ, Khoruts, A (B5) 2012; 107
Costello, SP, Conlon, MA, Vuaran, MS, Roberts-Thomson, IC, Andrews, JM (B15) 2015; 42
Ott, SJ, Waetzig, GH, Rehman, A, Moltzau-Anderson, J, Bharti, R, Grasis, JA, Cassidy, L, Tholey, A, Fickenscher, H, Seegert, D, Rosenstiel, P, Schreiber, S (B19) 2017; 152
Ianiro, G, Maida, M, Burisch, J, Simonelli, C, Hold, G, Ventimiglia, M, Gasbarrini, A, Cammarota, G (B12) 2018; 6
Sokol, H, Galperine, T, Kapel, N, Bourlioux, P, Seksik, P, Barbut, F, Scanzi, J, Chast, F, Batista, R, Joly, F, Joly, A-C, Collignon, A, Guery, B, Beaugerie, L (B10) 2016; 48
B2
El-Salhy, M, Hatlebakk, JG, Gilja, OH, Bråthen Kristoffersen, A, Hausken, T (B9) 2020; 69
Baunwall, SMD, Lee, MM, Eriksen, MK, Mullish, BH, Marchesi, JR, Dahlerup, JF, Hvas, CL (B13) 2020; 29–30
Khoruts, A, Staley, C, Sadowsky, MJ (B18) 2021; 18
Burz, SD, Abraham, A-L, Fonseca, F, David, O, Chapron, A, Béguet-Crespel, F, Cénard, S, Le Roux, K, Patrascu, O, Levenez, F (B14) 2019; 9
Trang, C, Scanzi, J, Galperine, T, Mosca, A, Batista, R, Sokol, H (B3) 2017; 24
Youngster, I, Sauk, J, Pindar, C, Wilson, RG, Kaplan, JL, Smith, MB, Alm, EJ, Gevers, D, Russell, GH, Hohmann, EL (B4) 2014; 58
Batista, R, Kapel, N, Megerlin, F (B11) 2015; 73
Cammarota, G, Ianiro, G, Tilg, H, Rajilić-Stojanović, M, Kump, P, Satokari, R, Sokol, H, Arkkila, P, Pintus, C, Hart, A (B7) 2017; 66
Satokari, R, Mattila, E, Kainulainen, V, Arkkila, PET (B6) 2015; 41
Biclot, A, Huys, GRB, Bacigalupe, R, D’hoe, K, Vandeputte, D, Falony, G, Tito, RY, Raes, J (B16) 2022; 10
van Nood, E, Vrieze, A, Nieuwdorp, M, Fuentes, S, Zoetendal, EG, de Vos, WM, Visser, CE, Kuijper, EJ, Bartelsman, J, Tijssen, JGP, Speelman, P, Dijkgraaf, MGW, Keller, JJ (B1) 2013; 368
Sintes, R, Navelli, G, Delage, S (B20) 2023; 368
Cammarota, G, Ianiro, G, Kelly, CR, Mullish, BH, Allegretti, JR, Kassam, Z, Putignani, L, Fischer, M, Keller, JJ, Costello, SP (B8) 2019; 68
Sintes R (e_1_3_3_21_2) 2023
e_1_3_3_6_2
e_1_3_3_5_2
Cammarota G (e_1_3_3_8_2) 2017
e_1_3_3_7_2
e_1_3_3_17_2
e_1_3_3_9_2
e_1_3_3_16_2
e_1_3_3_19_2
e_1_3_3_18_2
e_1_3_3_13_2
e_1_3_3_12_2
e_1_3_3_15_2
e_1_3_3_14_2
e_1_3_3_2_2
e_1_3_3_20_2
e_1_3_3_4_2
e_1_3_3_11_2
e_1_3_3_10_2
References_xml – volume: 13
  start-page: 508
  year: 2016
  end-page: 516
  ident: B17
  article-title: Understanding the mechanisms of faecal microbiota transplantation
  publication-title: Nat Rev Gastroenterol Hepatol
  doi: 10.1038/nrgastro.2016.98
  contributor:
    fullname: Sadowsky, MJ
– volume: 24
  start-page: 319
  year: 2017
  end-page: 325
  ident: B3
  article-title: Transplantation de microbiote fécal dans le cadre des infections à Clostridium difficile récidivantes: actualisation des recommandations pour la pratique clinique courante
  publication-title: Hepato-Gastro Oncol Dig
  doi: 10.1684/hpg.2017.1438
  contributor:
    fullname: Sokol, H
– volume: 73
  start-page: 323
  year: 2015
  end-page: 331
  ident: B11
  article-title: Fecal microbiota transplantation in recurrent Clostridium difficile infections framework and pharmaceutical preparation aspects
  publication-title: Ann Pharm Fr
  doi: 10.1016/j.pharma.2015.02.004
  contributor:
    fullname: Megerlin, F
– volume: 368
  year: 2023
  ident: B20
  article-title: Best step to freeze faecal microbiota transplants: native faeces, faecal suspension or pharmaceutical forms
  publication-title: GERPAC ;In Vol
  contributor:
    fullname: Delage, S
– volume: 41
  start-page: 46
  year: 2015
  end-page: 53
  ident: B6
  article-title: Simple faecal preparation and efficacy of frozen inoculum in faecal microbiota transplantation for recurrent Clostridium difficile infection--an observational cohort study
  publication-title: Aliment Pharmacol Ther
  doi: 10.1111/apt.13009
  contributor:
    fullname: Arkkila, PET
– volume: 29–30
  start-page: 100642
  year: 2020
  ident: B13
  article-title: Faecal microbiota transplantation for recurrent Clostridioides difficile infection: an updated systematic review and meta-analysis
  publication-title: EClinicalMedicine
  doi: 10.1016/j.eclinm.2020.100642
  contributor:
    fullname: Hvas, CL
– volume: 18
  start-page: 67
  year: 2021
  end-page: 80
  ident: B18
  article-title: Faecal microbiota transplantation for Clostridioides difficile: mechanisms and pharmacology
  publication-title: Nat Rev Gastroenterol Hepatol
  doi: 10.1038/s41575-020-0350-4
  contributor:
    fullname: Sadowsky, MJ
– volume: 66
  start-page: 569
  year: 2017
  end-page: 580
  ident: B7
  article-title: European consensus conference on faecal microbiota transplantation in clinical practice
  publication-title: Gut ;p In Vol ;BMJ Publishing Group
  contributor:
    fullname: Hart, A
– ident: B2
  article-title: Ansm . 2016 . La transplantation de microbiote fécal et son encadrement dans les essais cliniques
– volume: 10
  year: 2022
  ident: B16
  article-title: Effect of cryopreservation medium conditions on growth and isolation of gut anaerobes from human faecal samples
  publication-title: Microbiome
  doi: 10.1186/s40168-022-01267-2
  contributor:
    fullname: Raes, J
– volume: 107
  start-page: 761
  year: 2012
  end-page: 767
  ident: B5
  article-title: Standardized frozen preparation for transplantation of fecal microbiota for recurrent Clostridium difficile infection
  publication-title: Am J Gastroenterol
  doi: 10.1038/ajg.2011.482
  contributor:
    fullname: Khoruts, A
– volume: 9
  year: 2019
  ident: B14
  article-title: A Guide for Ex Vivo Handling and Storage of Stool Samples Intended for Fecal Microbiota Transplantation
  publication-title: Sci Rep
  doi: 10.1038/s41598-019-45173-4
  contributor:
    fullname: Levenez, F
– volume: 42
  start-page: 1011
  year: 2015
  end-page: 1018
  ident: B15
  article-title: Faecal microbiota transplant for recurrent Clostridium difficile infection using long-term frozen stool is effective: clinical efficacy and bacterial viability data
  publication-title: Aliment Pharmacol Ther
  doi: 10.1111/apt.13366
  contributor:
    fullname: Andrews, JM
– volume: 6
  start-page: 1232
  year: 2018
  end-page: 1244
  ident: B12
  article-title: Efficacy of different faecal microbiota transplantation protocols for Clostridium difficile infection: a systematic review and meta-analysis
  publication-title: United European Gastroenterol J
  doi: 10.1177/2050640618780762
  contributor:
    fullname: Cammarota, G
– volume: 69
  start-page: 859
  year: 2020
  end-page: 867
  ident: B9
  article-title: Efficacy of faecal microbiota transplantation for patients with irritable bowel syndrome in a randomised, double-blind, placebo-controlled study
  publication-title: Gut
  doi: 10.1136/gutjnl-2019-319630
  contributor:
    fullname: Hausken, T
– volume: 48
  start-page: 242
  year: 2016
  end-page: 247
  ident: B10
  article-title: Faecal microbiota transplantation in recurrent Clostridium difficile infection: recommendations from the French group of faecal microbiota transplantation
  publication-title: Dig Liver Dis
  doi: 10.1016/j.dld.2015.08.017
  contributor:
    fullname: Beaugerie, L
– volume: 368
  start-page: 407
  year: 2013
  end-page: 415
  ident: B1
  article-title: Duodenal infusion of donor feces for recurrent Clostridium difficile
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1205037
  contributor:
    fullname: Keller, JJ
– volume: 58
  start-page: 1515
  year: 2014
  end-page: 1522
  ident: B4
  article-title: Fecal microbiota transplant for relapsing Clostridium difficile infection using a frozen inoculum from unrelated donors: a randomized, open-label, controlled pilot study
  publication-title: Clin Infect Dis
  doi: 10.1093/cid/ciu135
  contributor:
    fullname: Hohmann, EL
– volume: 152
  start-page: 799
  year: 2017
  end-page: 811
  ident: B19
  article-title: Efficacy of sterile fecal filtrate transfer for treating patients with Clostridium difficile infection
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2016.11.010
  contributor:
    fullname: Schreiber, S
– volume: 68
  start-page: 2111
  year: 2019
  end-page: 2121
  ident: B8
  article-title: International consensus conference on stool banking for faecal microbiota transplantation in clinical practice
  publication-title: Gut
  doi: 10.1136/gutjnl-2019-319548
  contributor:
    fullname: Costello, SP
– volume-title: GERPAC
  year: 2023
  ident: e_1_3_3_21_2
  contributor:
    fullname: Sintes R
– start-page: 569
  volume-title: Gut
  year: 2017
  ident: e_1_3_3_8_2
  contributor:
    fullname: Cammarota G
– ident: e_1_3_3_11_2
  doi: 10.1016/j.dld.2015.08.017
– ident: e_1_3_3_4_2
  doi: 10.1684/hpg.2017.1438
– ident: e_1_3_3_7_2
  doi: 10.1111/apt.13009
– ident: e_1_3_3_15_2
  doi: 10.1038/s41598-019-45173-4
– ident: e_1_3_3_20_2
  doi: 10.1053/j.gastro.2016.11.010
– ident: e_1_3_3_10_2
  doi: 10.1136/gutjnl-2019-319630
– ident: e_1_3_3_18_2
  doi: 10.1038/nrgastro.2016.98
– ident: e_1_3_3_2_2
  doi: 10.1056/NEJMoa1205037
– ident: e_1_3_3_14_2
  doi: 10.1016/j.eclinm.2020.100642
– ident: e_1_3_3_17_2
  doi: 10.1186/s40168-022-01267-2
– ident: e_1_3_3_13_2
  doi: 10.1177/2050640618780762
– ident: e_1_3_3_16_2
  doi: 10.1111/apt.13366
– ident: e_1_3_3_19_2
  doi: 10.1038/s41575-020-0350-4
– ident: e_1_3_3_5_2
  doi: 10.1093/cid/ciu135
– ident: e_1_3_3_9_2
  doi: 10.1136/gutjnl-2019-319548
– ident: e_1_3_3_12_2
  doi: 10.1016/j.pharma.2015.02.004
– ident: e_1_3_3_6_2
  doi: 10.1038/ajg.2011.482
SSID ssj0006590
Score 2.5004737
Snippet Preparing fecal microbiota transplants immediately after donation is resource-intensive, and a proportion are destroyed following abnormal screening results....
ABSTRACT Preparing fecal microbiota transplants immediately after donation is resource-intensive, and a proportion are destroyed following abnormal screening...
SourceID proquest
crossref
asm2
pubmed
SourceType Aggregation Database
Index Database
StartPage e0073424
SubjectTerms Adult
Aged
Clinical Therapeutics
Clostridioides difficile
Clostridium Infections - microbiology
Clostridium Infections - therapy
Editor’s Pick
Fecal Microbiota Transplantation - methods
Feces - microbiology
Female
Freezing
Human Microbiome
Humans
Male
Middle Aged
Recurrence
Retrospective Studies
Title Use of frozen native feces for fecal microbiota transplantation in recurrent Clostridioides difficile infection: a simple way to improve the efficiency of donor feces preparation
URI https://www.ncbi.nlm.nih.gov/pubmed/39166867
https://journals.asm.org/doi/10.1128/aac.00734-24
https://www.proquest.com/docview/3095676562
Volume 68
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3bbtQwELVKEVVfECy3ctOAoC9tIJs4l-UNVaAK2qqIVupbZDsOROomq00Kaj-Lb-GDmLGdZFtYCXhZRUnW8e6cTDyTOWcYeyF4khSJX3g5jxKPF3HqCZ1Kz5_kkhfcl1FOgeL-Qbx7zD-cRCcrKz8XqpbOWvlKXfyRV_I_VsV9aFdiyf6DZftBcQduo33xEy2Mn39l42ObiC_m9YWutiqn4a2pyIqqB3GLuCGl1VpqBfWDqJrZqahciaHhsiin0LRzWlMPj7ysyxwHoM4ppUKf0ddrVZYY3ZQkKLz1XZh1a2mSErqrDSmNqzBv7fO6snPAwWZzbTXGHQh69ea2dNMjyYIvhm1niHZf9dRRw_qU_2dStrB5IRKhHuoZ1R5VcFVX6xwPxDcSGzWJfyHnRKTvDu3hNVzmd8dWCuAPLcViBiTgtgTPPsCs1yZR1DiyrXE7tx6ni_D1F5y0pteT3FK3f3-CBMSKEAhmc5Z3-TT8o2dTgyYiLMepbSVyRbG7O3SNXQ_Q_VGh4cdPg4Y9TtTvKBhB-nrxUutsrfsyLhFEMw0uL5eWxEBmLXR0i910QQy8tYi8zVZ0NWI3bFvT8xFb23cFGyO2eWil0c-34Whg-jXbsAmHg2j6-R32A7EMdQEWy2CxDAY9gFgGg2UYsAxXsAxlBT2W4TKWoccy9Fh-AwIskgGRDG0NDsmAsIMByTQng2Q3lwUk32XH798d7ex6rp-IJ3CB1npSJnFcKB1JP4py5atxpNJYapnoUOYqGtPWJNSxwIgT44Iix_giTpOUWnL7XIT32GpVV_oBgyDSciJl4Y-14nEsJzrkeTDxUx3mPFfhBntO1sucs2gyE2sHaYbWzoy1s4BvsJedbbOZ1ZZZct6zzvAZOn9lbipdnzVZSDKiCYZkwQa7bxHRj9QB6eHSI4_Y-nA7PWar7fxMP8EldiufGsT-Akrd2rc
link.rule.ids 315,783,787,27938,27939
linkProvider Colorado Alliance of Research Libraries
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Use+of+frozen+native+feces+for+fecal+microbiota+transplantation+in+recurrent+Clostridioides+difficile+infection%3A+a+simple+way+to+improve+the+efficiency+of+donor+feces+preparation&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.au=Sintes%2C+Rachel&rft.au=McLellan%2C+Paul&rft.au=Navelli%2C+Gabriele&rft.au=Landman%2C+C%C3%A9cilia&rft.date=2024-10-08&rft.eissn=1098-6596&rft.volume=68&rft.issue=10&rft.spage=e0073424&rft_id=info:doi/10.1128%2Faac.00734-24&rft_id=info%3Apmid%2F39166867&rft.externalDocID=39166867
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0066-4804&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0066-4804&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0066-4804&client=summon