The novel MFS efflux pump SxtP, regulated by the LysR-type transcriptional activator SxtR, is involved in the susceptibility to sulfamethoxazole/trimethoprim (SXT) and the pathogenesis of Acinetobacter baumannii

is a notorious opportunistic pathogen responsible for healthcare-associated infections worldwide. Efflux pumps play crucial roles in mediating antimicrobial resistance, motility, and virulence. In this study, we present the identification and characterization of the new efflux pump SxtP belonging to...

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Published inAntimicrobial agents and chemotherapy Vol. 68; no. 10; p. e0071224
Main Authors Gaona, Marc, Corral, Jordi, Campoy, Susana, Barbé, Jordi, Pérez Varela, María, Aranda, Jesús
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 28.08.2024
Subjects
Mechanisms of Resistance
Microbial Pathogenesis
LysR-type transcriptional regulator
Acinetobacter
MFS efflux pump
co-trimoxazole
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Summary:is a notorious opportunistic pathogen responsible for healthcare-associated infections worldwide. Efflux pumps play crucial roles in mediating antimicrobial resistance, motility, and virulence. In this study, we present the identification and characterization of the new efflux pump SxtP belonging to the MFS superfamily ( ajor acilitator uperfamily), along with its associated activator ysR type ranscriptional egulator (LTTR) SxtR, demonstrating their roles in sulfamethoxazole/trimethoprim (also known as co-trimoxazole or SXT) resistance, surface-associated motility and virulence.
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ISSN:0066-4804
1098-6596
1098-6596
DOI:10.1128/aac.00712-24