Optimal Control of the F1‑ATPase Molecular Motor

F1-ATPase is a rotary molecular motor that in vivo is subject to strong nonequilibrium driving forces. There is great interest in understanding the operational principles governing its high efficiency of free-energy transduction. Here we use a near-equilibrium framework to design a nontrivial contro...

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Bibliographic Details
Published inThe journal of physical chemistry letters Vol. 13; no. 51; pp. 11844 - 11849
Main Authors Gupta, Deepak, Large, Steven J., Toyabe, Shoichi, Sivak, David A.
Format Journal Article
LanguageEnglish
Published American Chemical Society 29.12.2022
Subjects
Physical Insights into Materials and Molecular Properties
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Summary:F1-ATPase is a rotary molecular motor that in vivo is subject to strong nonequilibrium driving forces. There is great interest in understanding the operational principles governing its high efficiency of free-energy transduction. Here we use a near-equilibrium framework to design a nontrivial control protocol to minimize dissipation in rotating F1 to synthesize adenosine triphosphate. We find that the designed protocol requires much less work than a naive (constant-velocity) protocol across a wide range of protocol durations. Our analysis points to a possible mechanism for energetically efficient driving of F1 in vivo and provides insight into free-energy transduction for a broader class of biomolecular and synthetic machines.
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ISSN:1948-7185
1948-7185
DOI:10.1021/acs.jpclett.2c03033