Multicompartment Synthetic Vesicles for Artificial Cell Applications

This review explores the cutting-edge development of multicompartment synthetic vesicles designed for artificial cell applications, drawing inspiration from the complex compartmentalization inherent in living cells. It delves into the recent advancements in engineering vesicles equipped with both me...

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Bibliographic Details
Published inACS applied engineering materials Vol. 2; no. 12; pp. 2758 - 2770
Main Authors Shin, Jooyong, Jang, Yeongseon
Format Journal Article
LanguageEnglish
Published American Chemical Society 27.12.2024
Subjects
Self-Assembly
Multicompartment Synthetic Vesicles
Emulsion Transfer
Artificial Cells
Microfluidics
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Summary:This review explores the cutting-edge development of multicompartment synthetic vesicles designed for artificial cell applications, drawing inspiration from the complex compartmentalization inherent in living cells. It delves into the recent advancements in engineering vesicles equipped with both membranous and membraneless organelles (vesicles-in-vesicles and coacervates-in-vesicles), offering a detailed examination of the methodologies and materials employed. This paper highlights the critical role of these multicompartment vesicles in simulating cellular microenvironments and functions, facilitating the spatial and temporal segregation of biochemical processes, such as signal transduction, gene expression, ATP synthesis, and energy production. Moreover, this review outlines potential future directions, emphasizing the importance of these vesicles in the evolution of artificial cells with a focus on their application in creating more sophisticated biomimetic systems.
ISSN:2771-9545
2771-9545
DOI:10.1021/acsaenm.3c00812