Kinetic Inertness of the Mn2+ Complexes Formed with AAZTA and Some Open-Chain EDTA Derivatives

The results of systematic equilibrium, kinetic, and relaxometric investigations carried out on the Mn2+ complexes of open-chain and AAZTA ligands indicate that the [Mn(CDTA)]2– complex has satisfactorily high kinetic inertness (t 1/2 = 12 h at pH = 7.4), which, in turn, may allow its use as a contra...

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Published inInorganic chemistry Vol. 51; no. 19; pp. 10065 - 10067
Main Authors Kálmán, Ferenc K, Tircsó, Gyula
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 01.10.2012
Subjects
Contrast Media - chemistry
Coordination Complexes - chemistry
Edetic Acid - analogs & derivatives
Edetic Acid - chemistry
Ligands
Manganese - chemistry
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Summary:The results of systematic equilibrium, kinetic, and relaxometric investigations carried out on the Mn2+ complexes of open-chain and AAZTA ligands indicate that the [Mn(CDTA)]2– complex has satisfactorily high kinetic inertness (t 1/2 = 12 h at pH = 7.4), which, in turn, may allow its use as a contrast agent in the field of magnetic resonance imaging (as a replacement for Gd3+-based agents).
Bibliography:ObjectType-Article-1
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ISSN:0020-1669
1520-510X
DOI:10.1021/ic300832e