Association of ABCA1 with Mild Cognitive Impairment

• Published in: International Journal of Gerontology Vol. 18; no. 2; pp. 85 - 90
• Main Authors: Yu Liu, Jia-Wei Duan, Zhiqin Hai, Zhizhong Wang, Shulan He
• Format: Journal Article
• Language: English
• Published: 社團法人台灣老人急重症醫學會 01.04.2024
• Subjects: ABCA1; genetic polymorphism; mild cognitive impairment
• ISSN: 1873-9598
• DOI: 10.6890/IJGE.202404_18(2).0005

Background: Mild cognitive impairment (MCI), as a neurodegenerative disease characterized by a moderate decline in one or more cognitive functions with a preserved autonomy in daily life activities, is the early stage and a high-risk state of Alzheimer's disease (AD). The adenosine triphosphate-binding cassette transporter A1 (ABCA1) is a cell membrane transporter protein involved in cholesterol reverse transport, sterol metabolism, and high-density lipoprotein (HDL) metabolism. The aim of this study was to investigate the relationship between polymorphism of C/T (rs4149268) in ABCA1 gene with MCI in a Chinese population. Methods: This study involved 1,654 subjects, including 278 MCI patients and 1376 healthy subjects. Genotypes of 1,616 samples were measured using matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS) technique. Results: The analysis of rs4149268 polymorphism of ABCA1 gene showed that there were significant differences between MCI and controls (p ＜ 0.05). When adjusting for age, sex, marital status, education, non-alcoholic fatty liver disease (NAFLD), and alcohol drinking, results showed that rs4149268 polymorphism was significantly correlated with MCI in codominant, dominant, and log-additive models. Logistic regression analysis showed that rs4149268 T/T carriers were 1.761 times more susceptible than C/C carriers (95% confidence interval: 1.108-2.800). Conclusions: Rs4149268 polymorphism of ABCA1 gene was shown to be a genetic risk factor for MCI.