Mesothelioma Heterogeneity : Potential Mechanisms

Mesothelioma is a rare aggressive cancer that develops from the mesothelium. Recent molecular analyses have defined four different types of mesothelioma based on gene expression and two major molecularly-defined groups based on prognosis. In this volume, potential mechanisms causing this heterogenei...

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Bibliographic Details
Main Author Felley-Bosco, Emanuela
Format eBook
LanguageEnglish
Published MDPI 01.01.2018
MDPI - Multidisciplinary Digital Publishing Institute
Subjects
Biology, life sciences
experimental mesothelioma models
Mathematics and Science
mesothelioma
NF2 signaling pathway
thema EDItEUR
tumor microenvironment
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Summary:Mesothelioma is a rare aggressive cancer that develops from the mesothelium. Recent molecular analyses have defined four different types of mesothelioma based on gene expression and two major molecularly-defined groups based on prognosis. In this volume, potential mechanisms causing this heterogeneity are explored. The different chapters include heterogeneity learned from experimental animal models in NF2/Hippo pathway signaling, stem cell signaling pathways, the tumor microenvironment, and micro RNA secretome. Novel aspects deserving attention such as the implication of long, non-coding RNA in disease heterogeneity are described. The volume also includes the description of tools useful to address some specific questions such as an assessment of the copy number variations of two tumor suppressors frequently mutated in mesothelioma or an investigation of Macrophage Inhibition Factor signaling in mesothelioma.
Bibliography:MODID-565f2b0520d:MDPI
ISBN:9783038974741
3038974749
3038974730
9783038974734
DOI:10.3390/books978-3-03897-474-1