B12-Mediated, Long Wavelength Photopolymerization of Hydrogels

Medical hydrogel applications have expanded rapidly over the past decade. Implantation in patients by noninvasive injection is preferred, but this requires hydrogel solidification from a low viscosity solution to occur in vivo via an applied stimuli. Transdermal photo-cross-linking of acrylated biop...

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Published inJournal of the American Chemical Society Vol. 137; no. 9; pp. 3372 - 3378
Main Authors Rodgers, Zachary L, Hughes, Robert M, Doherty, Laura M, Shell, Jennifer R, Molesky, Brian P, Brugh, Alexander M, Forbes, Malcolm D. E, Moran, Andrew M, Lawrence, David S
Format Journal Article
LanguageEnglish
Published American Chemical Society 11.03.2015
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Summary:Medical hydrogel applications have expanded rapidly over the past decade. Implantation in patients by noninvasive injection is preferred, but this requires hydrogel solidification from a low viscosity solution to occur in vivo via an applied stimuli. Transdermal photo-cross-linking of acrylated biopolymers with photoinitiators and lights offers a mild, spatiotemporally controlled solidification trigger. However, the current short wavelength initiators limit curing depth and efficacy because they do not absorb within the optical window of tissue (600–900 nm). As a solution to the current wavelength limitations, we report the development of a red light responsive initiator capable of polymerizing a range of acrylated monomers. Photoactivation occurs within a range of skin type models containing high biochromophore concentrations.
ISSN:0002-7863
1520-5126
DOI:10.1021/jacs.5b00182