High Incidence of Escherichia coli Strains Coharboring mcr-1 and blaNDM from Chickens

This study investigated the characteristics of Escherichia coli isolates carrying mcr-1-blaNDM from a chicken farm in China. Of the 78 E. coli isolates, 21 clonally unrelated isolates carried mcr-1-blaNDM. Diverse IncI2 plasmids disseminated mcr-1, while the dissemination of blaNDM was mediated by d...

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Published inAntimicrobial agents and chemotherapy Vol. 61; no. 3
Main Authors Liu, Bao-Tao, Song, Feng-Jing, Zou, Ming, Zhang, Qi-Di, Shan, Hu
Format Journal Article
LanguageEnglish
Published 1752 N St., N.W., Washington, DC American Society for Microbiology 01.03.2017
Subjects
beta-Lactamases
Drug Resistance, Multiple, Bacterial
Escherichia coli Infections
Escherichia coli Proteins
Gene Expression Regulation, Bacterial
Mechanisms of Resistance
Plasmids
Poultry Diseases
bla NDM
colocalization
Escherichia coli
mcr-1
high incidence
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Summary:This study investigated the characteristics of Escherichia coli isolates carrying mcr-1-blaNDM from a chicken farm in China. Of the 78 E. coli isolates, 21 clonally unrelated isolates carried mcr-1-blaNDM. Diverse IncI2 plasmids disseminated mcr-1, while the dissemination of blaNDM was mediated by diverse IncB/O plasmids. More striking was the colocalization of resistance genes mcr-1 and blaNDM-4 in an IncHI2/ST3 plasmid, which might pose a great challenge for public health.
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Citation Liu B-T, Song F-J, Zou M, Zhang Q-D, Shan H. 2017. High incidence of Escherichia coli strains coharboring mcr-1 and blaNDM from chickens. Antimicrob Agents Chemother 61:e02347-16. https://doi.org/10.1128/AAC.02347-16.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.02347-16