Combination therapy for psoriasis. Psoralens plus long-wave ultraviolet radiation with betamethasone valerate

In the treatment of psoriatic patients with psoralens plus long-wave ultraviolet radiation (PUVA), clearing of psoriatic lesions was obtained more quickly and with smaller doses of ultraviolet light when topically applied corticosteroid therapy was added. Twelve patients with symmetrical plaque-type...

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Bibliographic Details
Published inArchives of dermatology (1960) Vol. 115; no. 9; p. 1074
Main Authors Hanke, C W, Steck, W D, Roenigk, Jr, H H
Format Journal Article
LanguageEnglish
Published United States 01.09.1979
Subjects
Adult
Betamethasone - analogs & derivatives
Betamethasone Valerate - therapeutic use
Evaluation Studies as Topic
Female
Humans
Male
Methoxsalen - therapeutic use
Middle Aged
Photochemotherapy
Psoriasis - drug therapy
Ultraviolet Therapy
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Summary:In the treatment of psoriatic patients with psoralens plus long-wave ultraviolet radiation (PUVA), clearing of psoriatic lesions was obtained more quickly and with smaller doses of ultraviolet light when topically applied corticosteroid therapy was added. Twelve patients with symmetrical plaque-type psoriasis were given PUVA on one side of the body and PUVA plus betamethasone valerate on the other side in a paired comparison study. Ten of the patients had faster clearing of lesions on the side that was treated with PUVA and betamethasone than on the side treated with PUVA alone. The other two patients had equal clearing on both sides. All patients remained clear of lesions during maintenance with PUVA alone for at least five months after steroid therapy was discontinued. Combination therapy may save the patient time, expense, and unnecessary exposure to radiant energy.
ISSN:0003-987X
DOI:10.1001/archderm.1979.04010090024017