Treatment of hepatic metastases in ocular melanoma. Embolization of the hepatic artery with polyvinyl sponge and cisplatin

Patients with ocular melanoma have a high incidence of hepatic metastases, which primarily determine their length of survival. In an attempt to control the neoplastic disease in the liver, embolization of the hepatic artery with a combination of polyvinyl sponge (Ivalon) and a suspension of cisplati...

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Bibliographic Details
Published inJAMA : the journal of the American Medical Association Vol. 255; no. 22; p. 3152
Main Authors Carrasco, C H, Wallace, S, Charnsangavej, C, Papadopoulos, N E, Patt, Y Z, Mavligit, G M
Format Journal Article
LanguageEnglish
Published United States 13.06.1986
Subjects
Adult
Choroid Neoplasms
Cisplatin - administration & dosage
Combined Modality Therapy
Embolization, Therapeutic - methods
Hepatic Artery
Humans
Infusions, Intra-Arterial
Liver Neoplasms - diagnostic imaging
Liver Neoplasms - secondary
Liver Neoplasms - therapy
Male
Melanoma - diagnostic imaging
Melanoma - secondary
Melanoma - therapy
Polyvinyls
Suspensions
Tomography, X-Ray Computed
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Summary:Patients with ocular melanoma have a high incidence of hepatic metastases, which primarily determine their length of survival. In an attempt to control the neoplastic disease in the liver, embolization of the hepatic artery with a combination of polyvinyl sponge (Ivalon) and a suspension of cisplatin was performed in two patients with hepatic metastases from ocular melanoma. Dramatic regression of the hepatic metastases, lasting 19 and six months, occurred in these two patients after one or two such treatments. Our preliminary, albeit successful, experience with this therapeutic approach suggests that it may offer relatively prolonged periods of remission and warrants further investigation.
ISSN:0098-7484
DOI:10.1001/jama.1986.03370220114038