Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current I Ks by (R)-2-(2,4- Trifluoromethyl)-N-[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1H-benzo[e][1,4]diazepin-3-yl]acetamide

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Bibliographic Details
Published inJournal of medicinal chemistry Vol. 40; no. 24; pp. 3865 - 3868
Main Authors Selnick, Harold G, Liverton, Nigel J, Baldwin, John J, Butcher, John W, Claremon, David A, Elliott, Jason M, Freidinger, Roger M, King, Stella A, Libby, Brian E, McIntyre, Charles J, Pribush, David A, Remy, David C, Smith, Garry R, Tebben, Andrew J, Jurkiewicz, Nancy K, Lynch, Joseph J, Salata, Joseph J, Sanguinetti, Michael C, Siegl, Peter K. S, Slaughter, Donald E, Vyas, Kamlesh
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 21.11.1997
Amer Chemical Soc
Subjects
Chemistry, Medicinal
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Science & Technology
K+-CURRENT
DOFETILIDE
K(V)LQT1
RESOLUTION
AGENTS
DEATH
GUINEA-PIG
SUPPRESSION
PROTEINS
REPOLARIZATION
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ISSN:0022-2623
1520-4804
DOI:10.1021/jm970517u