Large-Scale Synthesis of the Anti-Cancer Marine Natural Product (+)-Discodermolide. Part 3:  Synthesis of Fragment C15 - 21

Smith's procedure of preparing fragment C15 - 21 (5) from common precursor 3 was optimized. The ease of plant operations made this six-step route successful for the production of several kilograms of this fragment with high purity.

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Bibliographic Details
Published inOrganic process research & development Vol. 8; no. 1; pp. 107 - 112
Main Authors Mickel, Stuart J, Sedelmeier, Gottfried H, Niederer, Daniel, Schuerch, Friedrich, Koch, Guido, Kuesters, E, Daeffler, Robert, Osmani, Adnan, Seeger-Weibel, Manuela, Schmid, E, Hirni, Alfred, Schaer, Karl, Gamboni, Remo, Bach, Andrew, Chen, Stephen, Chen, Weichun, Geng, Peng, Jagoe, Christopher T, Kinder, Frederick R, Lee, George T, McKenna, Joseph, Ramsey, Timothy M, Repič, Oljan, Rogers, Larry, Shieh, Wen-Chung, Wang, Run-Ming, Waykole, Liladhar
Format Journal Article
LanguageEnglish
Published American Chemical Society 01.01.2004
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Summary:Smith's procedure of preparing fragment C15 - 21 (5) from common precursor 3 was optimized. The ease of plant operations made this six-step route successful for the production of several kilograms of this fragment with high purity.
ISSN:1083-6160
1520-586X
DOI:10.1021/op034132z