Discovery of (2S)-1-(4-Amino-2,3,5- trimethylphenoxy)-3-{4-[4-(4- fluorobenzyl)phenyl]-1-piperazinyl}-2- propanol Dimethanesulfonate (SUN N8075):  A Dual Na+ and Ca2+ Channel Blocker with Antioxidant Activity

• Published in: Journal of medicinal chemistry Vol. 43; no. 18; pp. 3372 - 3376
• Main Authors: Annoura, Hirokazu, Nakanishi, Kyoko, Toba, Tetsuya, Takemoto, Naohiro, Imajo, Seiichi, Miyajima, Atsuko, Tamura-Horikawa, Yoshiko, Tamura, Shigeki
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 07.09.2000; Amer Chemical Soc
• Subjects: Anticonvulsants. Antiepileptics. Antiparkinson agents; Biological and medical sciences; Chemistry, Medicinal; Life Sciences & Biomedicine; Medical sciences; Neuropharmacology; Neuroprotective agent; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Science & Technology; EXPERIMENTAL FOCAL ISCHEMIA; VITAMIN-E; LIPID-PEROXIDATION; ACUTE ISCHEMIC STROKE; MILD HYPOTHERMIA; SENSITIVE SODIUM-CHANNELS; RAT-BRAIN; D-ASPARTATE RECEPTOR; CALCIUM-CHANNEL; CELL-DEATH; Sodium Ions; Intraperitoneal administration; Intravenous administration; Rat; Nitrogen heterocycle; Central nervous system; Calcium antagonist; Cardiovascular disease; Lipids; Anticonvulsant; Ionic channel; Prevention; Synaptosome; Hydroxyether; Ischemia; Antagonist; Inhibition; Secondary alcohol; Chemical synthesis; Peroxidation; Aminoalcohol; Rodentia; Benzene derivatives; Neuroprotective agent; Antioxidant; Calcium Ions; In vitro; Biological activity; In vivo; Vertebrata; Mammalia; Neuron; Animal; Tertiary amine; Piperazine derivatives; Brain (vertebrata)
• ISSN: 0022-2623; 1520-4804
• DOI: 10.1021/jm000143w