Direct Synthesis of C4-Acyl Indoles via C–H Acylation
The direct synthesis of C4-acyl indoles deprived of C2 and C3 substituents has proven to be challenging, with scarce efficient synthetic routes being reported. Herein, we disclose a highly site-selective palladium-catalyzed C–H acylation for the construction of C4-acyl indoles via a Catellani–Lauten...
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Published in | Organic letters Vol. 26; no. 23; pp. 4998 - 5003 |
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Main Authors | , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
WASHINGTON
American Chemical Society
14.06.2024
Amer Chemical Soc |
Subjects | |
Online Access | Get full text |
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Summary: | The direct synthesis of C4-acyl indoles deprived of C2 and C3 substituents has proven to be challenging, with scarce efficient synthetic routes being reported. Herein, we disclose a highly site-selective palladium-catalyzed C–H acylation for the construction of C4-acyl indoles via a Catellani–Lautens cyclization strategy. In addition, we systematically studied the ortho C–H acylation mechanism of iodoaniline through density functional theory (DFT) calculations and combined experimental results to elucidate the principle of high chemoselectivity brought by triazine benzoate as an acylation reagent. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1523-7060 1523-7052 |
DOI: | 10.1021/acs.orglett.4c01658 |