Application of PAT Tools for the Safe and Reliable Production of a Dihydro-1H-imidazole

The application of two Process Analytical Technology (PAT) tools was studied and implemented for the safe and reliable synthesis of an advanced intermediate (4S,5R-7) of a member of the dihydro-1H-imidazole (1) class of compounds. Real time data were generated using ReactIR to track the complete bre...

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Bibliographic Details
Published inOrganic process research & development Vol. 15; no. 6; pp. 1458 - 1463
Main Authors Barrios Sosa, Ana C., Conway, Ryan, Williamson, R. Thomas, Suchy, James P., Edwards, William, Cleary, Thomas
Format Journal Article
LanguageEnglish
Japanese
Published American Chemical Society 18.11.2011
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Summary:The application of two Process Analytical Technology (PAT) tools was studied and implemented for the safe and reliable synthesis of an advanced intermediate (4S,5R-7) of a member of the dihydro-1H-imidazole (1) class of compounds. Real time data were generated using ReactIR to track the complete breakdown of phosgene precursors (2) to phosgene (3) and confirm the absence of these hazardous materials prior to batch transfer operations. In addition, the chiral resolution by crystallization of rac 7 was monitored by a Lasentec FBRM probe-based system. Implementation of the latter helped to track the crystallization process to minimize the risk of cocrystallization of undesired isomer 4R,5S-7.
ISSN:1083-6160
1520-586X
DOI:10.1021/op2001172