Free-Base Nicotine Is Nearly Absent in Aerosol from IQOS Heat-Not-Burn Devices, As Determined by 1H NMR Spectroscopy

Heat-not-burn products, eg, I quit ordinary smoking (IQOS), are becoming popular alternative tobacco products. The nicotine aerosol protonation state has addiction implications due to differences in absorption kinetics and harshness. Nicotine free-base fraction (αfb) ranges from 0 to 1. Herein, we r...

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Published inChemical research in toxicology Vol. 32; no. 6; pp. 974 - 976
Main Authors Meehan-Atrash, Jiries, Duell, Anna K, McWhirter, Kevin J, Luo, Wentai, Peyton, David H, Strongin, Robert M
Format Journal Article
LanguageEnglish
Published American Chemical Society 17.06.2019
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ISSN0893-228X
1520-5010
1520-5010
DOI10.1021/acs.chemrestox.9b00076

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Summary:Heat-not-burn products, eg, I quit ordinary smoking (IQOS), are becoming popular alternative tobacco products. The nicotine aerosol protonation state has addiction implications due to differences in absorption kinetics and harshness. Nicotine free-base fraction (αfb) ranges from 0 to 1. Herein, we report αfb for IQOS aerosols by exchange-averaged 1H NMR chemical shifts of the nicotine methyl protons in bulk aerosol and verified by headspace-solid phase microextraction-gas chromatography-mass spectrometry. The αfb ≈ 0 for products tested; likely a result of proton transfer from acetic acid and/or other additives in the largely aqueous aerosol. Others reported higher αfb for these products, however, their methods were subject to error due to solvent perturbation.
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ISSN:0893-228X
1520-5010
1520-5010
DOI:10.1021/acs.chemrestox.9b00076