Phosphatase-like Activity of Porous Nanorods of CeO2 for the Highly Stabilized Dephosphorylation under Interferences

• Published in: ACS applied materials & interfaces Vol. 11; no. 1; pp. 195 - 201
• Main Authors: Yao, Tianzhu, Tian, Zhimin, Zhang, Yinqing, Qu, Yongquan
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 09.01.2019
• Subjects: ceria; heterogeneous catalysis; DNA; dephosphorylation; catalytic stability
• ISSN: 1944-8244; 1944-8252
• DOI: 10.1021/acsami.8b17086

Nanoceria with phosphatase-like behavior shows its great potential for many important biological applications through a catalytic dephosphorylation process. Herein, we synthesize a series of porous nanorods of ceria (PN-CeO2) with the controllable surface Ce3+ fractions modulated by thermal annealing, understanding the correlations between their surface properties and reactivity for the dephosphorylation of p-nitrophenyl phosphate (p-NPP) and investigating their catalytic performance under various interferences. Our results suggest that PN-CeO2 with abundant surface defects deliver higher catalytic activity to break down p-NPP. Most importantly, PN-CeO2 exhibited a better adaptability over a wide pH range and preserved the catalytic activity over a wide temperature range from 20 to 80 °C, if compared with natural enzymes. Moreover, PN-CeO2 delivered the high catalytic stability against various interference ions. Their great prospects for practical applications were further demonstrated by dephosphorylation of DNA.