Controlling Much? Viral Control of Host Chromatin Dynamics

Viruses are exemplary molecular biologists and have been integral to scientific discovery for generations. It is therefore no surprise that nuclear replicating viruses have evolved to systematically take over host cell function through astoundingly specific nuclear and chromatin hijacking. In this r...

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Bibliographic Details
Published inAnnual review of virology Vol. 11; no. 1; pp. 171 - 191
Main Authors Kelnhofer-Millevolte, Laurel E, Arnold, Edward A, Nguyen, Daniel H, Avgousti, Daphne C
Format Journal Article
LanguageEnglish
Published United States Annual Reviews 01.09.2024
Subjects
Adenoviridae - genetics
Adenoviridae - physiology
adenovirus
Animals
Cell Nucleus - metabolism
Cell Nucleus - virology
chromatin
Chromatin - genetics
Chromatin - metabolism
Herpesviridae - genetics
Herpesviridae - physiology
herpesvirus
histones
Host-Pathogen Interactions
Humans
latency
nucleus
Virus Replication
nucleus
histones
chromatin
herpesvirus
adenovirus
latency
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Summary:Viruses are exemplary molecular biologists and have been integral to scientific discovery for generations. It is therefore no surprise that nuclear replicating viruses have evolved to systematically take over host cell function through astoundingly specific nuclear and chromatin hijacking. In this review, we focus on nuclear replicating DNA viruses—herpesviruses and adenoviruses—as key examples of viral invasion in the nucleus. We concentrate on critical features of nuclear architecture, such as chromatin and the nucleolus, to illustrate the complexity of the virus-host battle for resources in the nucleus. We conclude with a discussion of the technological advances that have enabled the discoveries we describe and upcoming steps in this burgeoning field.
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ISSN:2327-056X
2327-0578
2327-0578
DOI:10.1146/annurev-virology-100422-011616