Synthesis and Characterization of a New Red-Emitting Ca2+ Indicator, Calcium Ruby

Calcium Ruby m-Cl (X = H, Y = Cl) is a visible-light excited red-emitting calcium concentration ([Ca2+]) indicator dye (579/598 nm peak excitation/emission) with a side arm for conjugation via EDC or click chemistry. Its large molar extinction and high quantum yield rank it among the brightest long-...

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Bibliographic Details
Published inOrganic letters Vol. 9; no. 14; pp. 2629 - 2632
Main Authors Gaillard, Stéphane, Yakovlev, Aleksey, Luccardini, Camilla, Oheim, Martin, Feltz, Anne, Mallet, Jean-Maurice
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 05.07.2007
Amer Chemical Soc
Subjects
Calcium - chemistry
Chelating Agents - chemical synthesis
Chelating Agents - chemistry
Chemistry
Chemistry, Organic
Egtazic Acid - analogs & derivatives
Egtazic Acid - chemical synthesis
Egtazic Acid - chemistry
Electrochemistry
Fluorescence
Indicators and Reagents - chemical synthesis
Indicators and Reagents - chemistry
Physical Sciences
Science & Technology
Spectrophotometry, Infrared
Trifluoroacetic Acid - chemistry
FLUORESCENT INDICATORS
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Summary:Calcium Ruby m-Cl (X = H, Y = Cl) is a visible-light excited red-emitting calcium concentration ([Ca2+]) indicator dye (579/598 nm peak excitation/emission) with a side arm for conjugation via EDC or click chemistry. Its large molar extinction and high quantum yield rank it among the brightest long-wavelength Ca2+ indicators. Calcium Ruby is a promising alternative to existing dyes for imaging [Ca2+] in multicolor fluorescence applications or in the presence of yellow-green cellular autofluorescence.
Bibliography:ObjectType-Article-1
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ISSN:1523-7060
1523-7052
DOI:10.1021/ol070648h