Reactive Oxygen Species Scavenging Capacity of Functional Fullerenes in Solution and in Macrophage Cells

Fullerene derivatives are known radical scavengers and quenchers of reactive oxygen species and have been studied as promising antioxidative agents in biological systems, yet the correlation between the structural features and their efficiency has not been well understood. In this report, we synthes...

Full description

Saved in:
Bibliographic Details
Published inACS applied nano materials Vol. 7; no. 15; pp. 18036 - 18044
Main Authors Biswas, Rohin, Manley, Brock J., Xiao, Li, Siringan, Mark John, Crichton, Ryan A., Stein, Joshua B., Dawar, Abhiram, Lee, Ki-Bum, Jin, Li, Li, Xudong, Zhang, Jianyuan
Format Journal Article
LanguageEnglish
Published American Chemical Society 09.08.2024
Subjects
reactive oxygen species (ROS)
electron paramagnetic resonance (EPR)
antioxidants
macrophage cells
fullerene
Online AccessGet full text

Cover

More Information
Summary:Fullerene derivatives are known radical scavengers and quenchers of reactive oxygen species and have been studied as promising antioxidative agents in biological systems, yet the correlation between the structural features and their efficiency has not been well understood. In this report, we synthesized eight representative water-soluble fullerene derivatives and compared their radical scavenging properties via electron paramagnetic resonance in solution and antioxidative capacity in the H2O2-treated RAW 264.7 macrophage cell model. Through this systematic study, we identified multiple key parameters contributing to their radical scavenging and antioxidative effects, including the number and identity of functional groups on the C60 cage, the size of aggregates, and their cellular uptake in RAW 264.7 cells.
ISSN:2574-0970
2574-0970
DOI:10.1021/acsanm.4c03467