Deranged aortic intima-media thickness, plasma triglycerides and granulopoiesis in Sl/Sl^d mice

• Published in: Mediators of Inflammation Vol. 2004; no. 5-6; pp. 335 - 341
• Main Authors: Dileepan, Kottarappat N., Johnston, Thomas P., Li, Yuai, Tawfik, Ossama, Stechschulte, Daniel J.
• Format: Journal Article
• Language: English
• Published: Hindawi Limiteds 01.12.2004
• Subjects: Mast cell deficiency; Hypertriglyceridemia; High-fat diet; Stem cell factor deficiency; Intima media thickness
• ISSN: 0962-9351; 1466-1861
• DOI: 10.1080/09629350400008794

STUDIES were carried out to evaluate the impact of a high-fat dietary regimen on aortic wall thickness, peripheral blood leukocyte profile, and plasma cholesterol and triglyceride levels in the mast celldeficient Sl/Sl^d mouse. The results demonstrated that the mean aortic wall thickness of Sl/Sl^d mice was significantly higher than their normal littermates, and were increased in both genotypes after a 17-day high-fat regimen. In comparison with normal littermates, Sl/Sl^d genotypes had elevated levels of plasma triglycerides with normal levels of plasma cholesterol, and the high-fat diet markedly lowered the triglyceride levels. Total peripheral blood leukocytes, the monocyte and granulocyte counts, and hemoglobin levels were significantly lower in Sl/Sl^d mice, although the number of lymphocytes, eosinophils and basophils were the same in both genotypes. Interestingly, the high-fat diet regimen elevated leukocyte counts and the number of monocytes and granulocytes in Sl/Sl^d mice.