Large-dose bleomycin therapy and pulmonary toxicity. A possible role of prior radiotherapy

• Published in: JAMA : the journal of the American Medical Association Vol. 235; no. 11; p. 1117
• Main Authors: Samuels, M L, Johnson, D E, Holoye, P Y, Lanzotti, V J
• Format: Journal Article
• Language: English
• Published: United States 15.03.1976
• Subjects: Adolescent; Adult; Bleomycin - administration & dosage; Bleomycin - adverse effects; Bleomycin - therapeutic use; Dyspnea - chemically induced; Humans; Hypoxia - chemically induced; Lung - drug effects; Male; Middle Aged; Pneumonia - chemically induced; Radiation Dosage; Radiation-Sensitizing Agents - adverse effects; Radiography, Thoracic; Testicular Neoplasms - drug therapy; Testicular Neoplasms - radiotherapy
• ISSN: 0098-7484
• DOI: 10.1001/jama.1976.03260370025026

Bleomycin sulfate pulmonary toxicity was encountered in nine of 101 patients receiving high-dose therapy for widespread testicular cancer. The pulmonary presentation was separable into two categories: (1) an early or minimal from with dyspnea on exertion, minimal roentgenographic findings, and normal arterial partial pressure of oxygen at rest and (2) a severe form, with prominent roentgenographic findings and hypoxemia at rest. All five patients with the severe form died, while the remaining four patients with the minimal presentation recovered. Prior thoracic radiotherapy appeared to predispose to bleomycin pulmonary toxicity, as this complication developed in five of 12 patients receiving prior chest radiotherapy vs four of 89 not receiving radiotherapy (p less than .001). The fatality rate of 5% with high-dose bleomycin therapy is acceptable in view of the 75% response rate and substantially improved survival achieved with bleomycin combination chemotherapy in metastatic testicular cancer.