Age and homocystein were risk factor for peripheral arterial disease in elderly with type 2 diabetes mellitus

• Published in: Acta medica Indonesiana Vol. 42; no. 2; pp. 94 - 99
• Main Authors: Kuswardhani, R A Tuty, Suastika, Ketut
• Format: Journal Article
• Language: English
• Published: Indonesia 01.04.2010
• Subjects: Age Factors; Aged; Aged, 80 and over; Case-Control Studies; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - epidemiology; Homocysteine - blood; Humans; Incidence; Indonesia - epidemiology; Peripheral Arterial Disease - blood; Peripheral Arterial Disease - epidemiology; Peripheral Arterial Disease - etiology; Risk Factors; Indonesia
• ISSN: 0125-9326

to find out the magnitude of risk of some traditional and non-traditional risk factors for PAD event in the elderly with Type 2 diabetes mellitus (T2DM) patients. a case-control study involved 40 subjects of each arms (case and control group) at Geriatric Outpatient Clinic Sanglah Hospital, Denpasar, Bali, Indonesia was conducted. the study showed that compared to patients without PAD, patients with PAD had higher age (70.7 vs. 65.0 years; p<0.001), lower waist circumference (82.7 vs. 91.3 cm; p=0.019), lower triglyceride levels (127.8 vs. 173.9 mg/dl; p=0.016), and higher homocystein levels (13.4 vs. 11.5 mmol/L, p=0.023); while other variables revealed no any significantly difference between two groups. Although no any significant difference, subjects with PAD tend to do exercise less prevalent, consumed anti-hyperlipidemic and anti-thrombotic more frequent compared to subjects without PAD. High age (70-80 years) has risk 7.4 time than those lower age (60-69 years), and high homocystein level (> or =11 mmol/L) has risk 2.5 time than those with lower level to develop PAD. By multivariate analysis (logistic regression), only age has a role in PAD event, while homocystein tend to be risk factor for PAD event. some traditional risk factors and non-traditional risk factors unproved as risk factors for PAD event in the elderly with type 2 diabetes. Older age and homocystein level were risk factors for PAD event in the elderly with type 2 diabetes subjects.