DNA-Mediated Graphene Oxide/Platinum Nanozymes for Label-Free Colorimetric Detection of Hg2

Mercury ions (Hg2+) have persistent bioaccumulation and high toxicity, which can severely damage the ecological system and human health. Therefore, sensitive methods are required for Hg2+ analysis. Herein, a DNA-mediated growth strategy was developed for the synthesis of platinum nanoparticles (PtNP...

Full description

Saved in:
Bibliographic Details
Published inACS applied nano materials Vol. 6; no. 16; pp. 15224 - 15233
Main Authors Jia, Jilai, Du, Xiaoping, Lv, Xuqin, Xie, Fang, Zhou, Jiaojiao, Cai, Jie
Format Journal Article
LanguageEnglish
Published American Chemical Society 25.08.2023
Subjects
mercury ion detection
platinum nanoparticles
graphene oxide
colorimetric biosensor
DNA
Online AccessGet full text

Cover

More Information
Summary:Mercury ions (Hg2+) have persistent bioaccumulation and high toxicity, which can severely damage the ecological system and human health. Therefore, sensitive methods are required for Hg2+ analysis. Herein, a DNA-mediated growth strategy was developed for the synthesis of platinum nanoparticles (PtNPs) on the surface of graphene oxide (GO). The resulting GO-DNA-PtNPs displayed excellent peroxidase-mimicking activity in a sequence-dependent manner. The peroxidase-mimicking activity could be significantly inhibited by Hg2+ because of the specific trapping of Hg2+ by thymine bases (T–Hg2+–T) and in situ reduction of Hg2+ by PtNPs on the GO surface. Under optimal conditions, there was a good linear range from 1 pM to 1 μM with a detection limit of 2.2 pM for Hg2+ analysis. This sensor demonstrated excellent analytical performance for assessing Hg2+ in complex lake waters. This work provides an effective strategy for the preparation of PtNP-based nanozymes and broadens the applications of PtNPs for biosensing.
ISSN:2574-0970
2574-0970
DOI:10.1021/acsanm.3c02986