Cu (I)-Catalyzed Synthesis of Polysubstituted Pyrroles from Dialkyl Ethylenedicarboxylates and β-Enamino Ketones or Esters in the Presence of O2

A straightforward method for the synthesis of polysubstituted pyrroles was achieved easily from oxidative cyclization of β-enamino ketones or esters and alkynoates catalyzed by CuI in the presence of O2.

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Bibliographic Details
Published inJournal of organic chemistry Vol. 75; no. 15; pp. 5395 - 5397
Main Authors Yan, Ru-Long, Luo, Jia, Wang, Chuan-Xin, Ma, Chao-Wei, Huang, Guo-Sheng, Liang, Yong-Min
Format Journal Article
LanguageEnglish
Published Washington, DC American Chemical Society 06.08.2010
Subjects
Carboxylic Acids - chemistry
Catalysis
Chemistry
Copper - chemistry
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with only one n hetero atom and condensed derivatives
Ketones - chemistry
Magnetic Resonance Spectroscopy
Mass Spectrometry
Organic chemistry
Oxygen - chemistry
Preparations and properties
Pyrroles - chemistry
Catalytic reaction
Nitrogen heterocycle
Enamine
Ketone
Pyrrole derivatives
Ester
Oxygen molecules
Cyclization
Alkynoic acid
Diester
Copper I
Copper I Iodides
Oxidation
Chemical synthesis
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Summary:A straightforward method for the synthesis of polysubstituted pyrroles was achieved easily from oxidative cyclization of β-enamino ketones or esters and alkynoates catalyzed by CuI in the presence of O2.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-3263
1520-6904
DOI:10.1021/jo101022k