Three New Taxane Diterpenoids from Taxus s umatrana

Phytochemical investigation of taxane diterpenoidal content of an acetone extract of the leaves and twigs of Taxus sumatrana has resulted in the isolation of three new taxoid compounds, tasumatrols E (1), F (2), and G (3) together with 13 known taxanes (5−16). The structures of these taxanes as well...

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Published inJournal of natural products (Washington, D.C.) Vol. 68; no. 1; pp. 90 - 93
Main Authors Shen, Ya-Ching, Cheng, Kuen-Ching, Lin, Yun-Chi, Cheng, Yuan-Bin, Khalil, Ashraf Taha, Guh, Jih-Hwa, Chien, Ching-Te, Teng, Che-Ming, Chang, Yao-To
Format Journal Article
LanguageEnglish
Published American Chemical Society 28.01.2005
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Summary:Phytochemical investigation of taxane diterpenoidal content of an acetone extract of the leaves and twigs of Taxus sumatrana has resulted in the isolation of three new taxoid compounds, tasumatrols E (1), F (2), and G (3) together with 13 known taxanes (5−16). The structures of these taxanes as well as their derivatives were established on the basis of spectroscopic analyses, especially 1D and 2D NMR. Compounds 1, 2, 12, and 16 exhibited significant cytotoxicity against human A-498, NCI-H226, A549, and PC-3 tumor cells.
ISSN:0163-3864
1520-6025
DOI:10.1021/np040132w