Acylphloroglucinol Derivatives from Mahurea p alustris

Five new acylphloroglucinol derivatives, mahureones A−E (1, 3−6), have been isolated from the leaves of Mahurea palustris, and their structures determined by spectroscopic means. During the isolation process, several byproducts (7−9) were formed by reaction of one of the isoprenyl side chains with T...

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Published inJournal of natural products (Washington, D.C.) Vol. 68; no. 7; pp. 979 - 984
Main Authors Massiot, Georges, Long, Christophe, David, Bruno, Serrano, Marie-Jeanne, Daubié, Florence, Alby, Frédéric, Ausseil, Frédéric, Knibiehler, Martine, Moretti, Christian, Hoffmann, Jean-Sébastien, Cazaux, Christophe, Lavaud, Catherine
Format Journal Article
LanguageEnglish
Published American Chemical Society 22.07.2005
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Summary:Five new acylphloroglucinol derivatives, mahureones A−E (1, 3−6), have been isolated from the leaves of Mahurea palustris, and their structures determined by spectroscopic means. During the isolation process, several byproducts (7−9) were formed by reaction of one of the isoprenyl side chains with TFA, water, and acetonitrile. All the compounds were assayed for their ability to inhibit human DNA polymerase β. The most active compounds, mahureones A (1) and D (5), exhibited IC50 values in the 10 μM range.
ISSN:0163-3864
1520-6025
DOI:10.1021/np049676o