C 3 v Symmetric Receptors Show High Selectivity and High Affinity for Phosphate

The binding of phosphate to tripodal metalloreceptors 1 and 2 is reported. Receptors 1 and 2 are C3 v symmetric, designed to complement three sides of a tetrahedron. The receptors derive from tripodal ligands that are preorganized through binding to a central Cu(II) atom. These metalloreceptors demo...

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Bibliographic Details
Published inJournal of the American Chemical Society Vol. 125; no. 14; pp. 4026 - 4027
Main Authors Tobey, Suzanne L, Jones, Benjamin D, Anslyn, Eric V
Format Journal Article
LanguageEnglish
Published American Chemical Society 09.04.2003
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Summary:The binding of phosphate to tripodal metalloreceptors 1 and 2 is reported. Receptors 1 and 2 are C3 v symmetric, designed to complement three sides of a tetrahedron. The receptors derive from tripodal ligands that are preorganized through binding to a central Cu(II) atom. These metalloreceptors demonstrate high selectivity and affinity for the molecular recognition of phosphate in aqueous media at neutral pH. The binding of phosphate and other anions to the cavities of receptors 1 and 2 was monitored by UV/vis titration techniques. Binding algorithms were used to determine the affinity of phosphate to 1 and 2 with association values (K a) of 2.5 × 104 and 1.5 × 104 M-1, respectively.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja021390n