Iodine Catalyzed Oxidative Synthesis of Quinazolin-4(3H)‑ones and Pyrazolo[4,3‑d]pyrimidin-7(6H)‑ones via Amination of sp3 C–H Bond
Molecular iodine catalyzed oxidative coupling of 2-aminobenzamides with aryl methyl ketones produced 2-aryl quinazolin-4(3H)-ones. The reaction performed well in the absence of any metal or ligand. The quantity of iodine played a very crucial role in this transformation in order to selectively get...
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Published in | Journal of organic chemistry |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
American Chemical Society
23.06.2015
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Online Access | Get full text |
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Summary: | Molecular iodine catalyzed oxidative coupling of 2-aminobenzamides with aryl methyl ketones produced 2-aryl quinazolin-4(3H)-ones. The reaction performed well in the absence of any metal or ligand. The quantity of iodine played a very crucial role in this transformation in order to selectively get 2-aryl quinazolin-4(3H)-ones. The utility of this protocol for synthesis of pyrazolo[4,3-d]pyrimidin-7(6H)-ones including a key intermediate involved in sildenafil synthesis has also been demonstrated. |
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ISSN: | 0022-3263 1520-6904 |
DOI: | 10.1021/acs.joc.5b00989 |