Emerging concepts targeting immune checkpoints in cancer and autoimmunity

• Other Authors: Yoshimura, Akihiko
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer, 2017.
• Series: Current topics in microbiology and immunology ; 410.
• Subjects: Immune response > Regulation.; Cancer > Immunological aspects.; elektronické knihy; electronic books

This volume reviews the current state of research on immune checkpoints and offers novel concepts. It discusses the two most important immune checkpoints: T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1). It shows that antagonistic antibodies against these two molecules...