Hydrogen Peroxide Derived From Beating Heart Mediates Coronary Microvascular Dilation During Tachycardia

• Published in: Arteriosclerosis, thrombosis, and vascular biology Vol. 27; no. 5; pp. 1057 - 1063
• Main Authors: Kokusho, Yasunori, Komaru, Tatsuya, Takeda, Satoru, Takahashi, Katsuaki, Koshida, Ryoji, Shirato, Kunio, Shimokawa, Hiroaki
• Format: Journal Article
• Language: English
• Published: American Heart Association, Inc 01.05.2007

OBJECTIVE—Coronary flow is closely correlated to the myocardial metabolic demand. We tested the hypothesis that hydrogen peroxide (H2O2) derived from beating hearts mediates metabolic coronary microvascular dilation. METHODS AND RESULTS—We used a bioassay method in which an isolated microvessel is p...