Abstract 15653: Insulin Resistance is Associated With Low Systemic Vascular Resistance in Non-Diabetic Individuals After Cardiac Surgery
BackgroundPost-operative decreases in systemic vascular resistance (SVR) are associated with prolonged ICU stay and increased morbidity. Insulin resistance (IR) has been described as a component of systemic inflammation and endothelial dysfunction which may lead to low SVR. We hypothesised that IR i...
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Published in | Circulation (New York, N.Y.) Vol. 138; no. Suppl_1 Suppl 1; p. A15653 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
by the American College of Cardiology Foundation and the American Heart Association, Inc
06.11.2018
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Abstract | BackgroundPost-operative decreases in systemic vascular resistance (SVR) are associated with prolonged ICU stay and increased morbidity. Insulin resistance (IR) has been described as a component of systemic inflammation and endothelial dysfunction which may lead to low SVR. We hypothesised that IR in non-diabetic individuals undergoing cardiac surgery would be associated with clinically significant low post-operative SVR.MethodsWe analysed data from a prospective cohort study of 699 non-diabetic individuals who underwent cardiac surgery at a large tertiary hospital between 2012 and 2017. All participants had post-operative SVR recorded during ICU stay. Patients with a recorded SVR ≤ 800 dyn·s·cm were considered low SVR (n = 399). Fasting insulin and glucose were collected. Patients above median homeostatic model assessment of IR (HOMA-IR) were considered insulin resistant.ResultsHOMA-IR, as well as increasing age, male sex, total cholesterol, high-density lipoprotein (HDL), BMI, and history of coronary disease were significantly associated with low SVR on bivariate analysis (p < 0.05). Exercise capacity and dysglycemia were similar between groups. Using a multivariate logistic regression model, we found HOMA-IR (OR = 1.7, CI 95%1.2-2.4; p = 0.001) independently predicted low SVR in non-diabetic patients when adjusted for age, sex, and other risk factors but not BMI. Male sex (OR = 3.9, CI 95%2.6-5.9; p < 0.001) had the strongest independent association with low SVR.ConclusionsIR is independently associated with clinically significant low post-operative SVR in non-diabetic individuals who underwent cardiac surgery. This data supports pathophysiological hypotheses that suggest IR as a component of vascular dysfunction resulting in low SVR. This novel, preliminary finding warrants further research of IR as a clinical tool for predicting low SVR in other non-cardiac surgical patients. |
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AbstractList | BackgroundPost-operative decreases in systemic vascular resistance (SVR) are associated with prolonged ICU stay and increased morbidity. Insulin resistance (IR) has been described as a component of systemic inflammation and endothelial dysfunction which may lead to low SVR. We hypothesised that IR in non-diabetic individuals undergoing cardiac surgery would be associated with clinically significant low post-operative SVR.MethodsWe analysed data from a prospective cohort study of 699 non-diabetic individuals who underwent cardiac surgery at a large tertiary hospital between 2012 and 2017. All participants had post-operative SVR recorded during ICU stay. Patients with a recorded SVR ≤ 800 dyn·s·cm were considered low SVR (n = 399). Fasting insulin and glucose were collected. Patients above median homeostatic model assessment of IR (HOMA-IR) were considered insulin resistant.ResultsHOMA-IR, as well as increasing age, male sex, total cholesterol, high-density lipoprotein (HDL), BMI, and history of coronary disease were significantly associated with low SVR on bivariate analysis (p < 0.05). Exercise capacity and dysglycemia were similar between groups. Using a multivariate logistic regression model, we found HOMA-IR (OR = 1.7, CI 95%1.2-2.4; p = 0.001) independently predicted low SVR in non-diabetic patients when adjusted for age, sex, and other risk factors but not BMI. Male sex (OR = 3.9, CI 95%2.6-5.9; p < 0.001) had the strongest independent association with low SVR.ConclusionsIR is independently associated with clinically significant low post-operative SVR in non-diabetic individuals who underwent cardiac surgery. This data supports pathophysiological hypotheses that suggest IR as a component of vascular dysfunction resulting in low SVR. This novel, preliminary finding warrants further research of IR as a clinical tool for predicting low SVR in other non-cardiac surgical patients. |
Author | Mack, Jane Carew, David Wilson, Andrew Newcomb, Andrew Tiong, Jonathan Reid, David Baradi, Arul Duve, Karen |
AuthorAffiliation | Dept of Cardiothoracics, St Vincent’s Hosp Melbourne, Fitzroy, Australia Dept of Medicine, Univ of Melbourne, Parkville, Australia Dept of Critical Care Medicine, St Vincent’s Hosp Melbourne, Fitzroy, Australia Dept of Cardiology, St Vincent’s Hosp Melbourne, Fitzroy, Australia |
AuthorAffiliation_xml | – name: Dept of Cardiothoracics, St Vincent’s Hosp Melbourne, Fitzroy, Australia – name: Dept of Medicine, Univ of Melbourne, Parkville, Australia – name: Dept of Cardiology, St Vincent’s Hosp Melbourne, Fitzroy, Australia – name: Dept of Critical Care Medicine, St Vincent’s Hosp Melbourne, Fitzroy, Australia |
Author_xml | – sequence: 1 givenname: David surname: Carew fullname: Carew, David organization: Dept of Medicine, Univ of Melbourne, Parkville, Australia – sequence: 2 givenname: Jonathan surname: Tiong fullname: Tiong, Jonathan organization: Dept of Medicine, Univ of Melbourne, Parkville, Australia – sequence: 3 givenname: David surname: Reid fullname: Reid, David organization: Dept of Critical Care Medicine, St Vincent’s Hosp Melbourne, Fitzroy, Australia – sequence: 4 givenname: Karen surname: Duve fullname: Duve, Karen organization: Dept of Cardiothoracics, St Vincent’s Hosp Melbourne, Fitzroy, Australia – sequence: 5 givenname: Jane surname: Mack fullname: Mack, Jane organization: Dept of Cardiothoracics, St Vincent’s Hosp Melbourne, Fitzroy, Australia – sequence: 6 givenname: Arul surname: Baradi fullname: Baradi, Arul organization: Dept of Cardiology, St Vincent’s Hosp Melbourne, Fitzroy, Australia – sequence: 7 givenname: Andrew surname: Newcomb fullname: Newcomb, Andrew organization: Dept of Cardiothoracics, St Vincent’s Hosp Melbourne, Fitzroy, Australia – sequence: 8 givenname: Andrew surname: Wilson fullname: Wilson, Andrew organization: Dept of Medicine, Univ of Melbourne, Parkville, Australia |
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Snippet | BackgroundPost-operative decreases in systemic vascular resistance (SVR) are associated with prolonged ICU stay and increased morbidity. Insulin resistance... |
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Title | Abstract 15653: Insulin Resistance is Associated With Low Systemic Vascular Resistance in Non-Diabetic Individuals After Cardiac Surgery |
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