Cancer Stem Cells

• Published in: Holland‐Frei Cancer Medicine pp. 1 - 12
• Main Authors: Bushnell, Grace G., Granger, Jill, Wicha, Max S.
• Format: Reference
• Language: English
• Published: Hoboken, NJ, USA John Wiley & Sons, Inc 26.02.2017; 21.10.2022
• Subjects: self‐renewal; tumor‐initiating cells; Notch; therapeutic targeting; cancer stem cells (CSCs); plasticity; EMT; heterogeneity; Hedgehog; metastasis; dormancy; cancer stem cells; MET; Wnt/β‐catenin

There is substantial evidence that many, if not most, tumors contain a subpopulation of cells that display stem cell properties. These “cancer stem cells” (CSC) play an important role in tumor initiation and propagation. Furthermore, these cells may mediate metastasis and resistance to cancer therap...