Iodination of aromatic residues in peptides by reaction with IPy(2)BF(4)

A simple and straightforward approach to selectively iodinate Tyr residues on peptides using IPy(2)BF(4) is described which is compatible with Met residues on the side chain; preliminary studies reveal that the method is also suitable to iodinate Phe derivatives.

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Bibliographic Details
Published inChemical communications (Cambridge, England) no. 13; pp. 1505 - 1506
Main Authors Barluenga, J, GarciaMartin, MA, Gonzalez, JM, Clapes, P, Valencia, G
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 07.07.1996
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
RADIOIODINATION
PROTEINS
BRAIN
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Summary:A simple and straightforward approach to selectively iodinate Tyr residues on peptides using IPy(2)BF(4) is described which is compatible with Met residues on the side chain; preliminary studies reveal that the method is also suitable to iodinate Phe derivatives.
ISSN:1359-7345
DOI:10.1039/cc9960001505