SIGMA-LIGANDS WITH SUBNANOMOLAR AFFINITY AND PREFERENCE FOR THE SIGMA(2) BINDING-SITE .1. 3-(OMEGA-AMINOALKYL)-1H-INDOLES

• Published in: Journal of medicinal chemistry Vol. 38; no. 11; pp. 1998 - 2008
• Main Authors: PERREGAARD, J, MOLTZEN, EK, MEIER, E, SANCHEZ, C
• Format: Journal Article
• Language: English
• Published: WASHINGTON Amer Chemical Soc 26.05.1995
• Subjects: Chemistry, Medicinal; Life Sciences & Biomedicine; Pharmacology & Pharmacy; Science & Technology; ANTAGONIST; 5-HT1A RECEPTOR; RAT; HALOPERIDOL; BMY-14802; INVITRO; DOPAMINE; MODEL; GUINEA-PIG BRAIN; POTENTIAL ANTIPSYCHOTIC AGENT

A series of 4-(1H-indol-3-yl)-1-butyl-substituted 4-phenylpiperidines, 4-phenyl-1,2,3,6-tetra-hydropyridines, and 4-phenylpiperazines was synthesized. The phenyl group was optionally substituted with 4-fluoro or 2-methoxy substituents. High affinity for both sigma(1) and sigma(2) binding sites was a...