SYNTHESIS AND SELECTIVE CLEAVAGE OF AN OLIGODEOXYNUCLEOTIDE CONTAINING A BRIDGED NONCHIRAL INTERNUCLEOTIDE 3'-PHOSPHORAMIDATE LINKAGE

A self complementary oligodeoxynucleotide dodecamer containing an achiral bridged 3'-phosphoramidate linkage 3'-NH-P-O-5' has been prepared using the solid phase phosphoramidite procedure. Cleavage of the P-N bond can be accomplished selectively by mild acidolysis.

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Bibliographic Details
Published inTetrahedron letters Vol. 33; no. 48; pp. 7319 - 7322
Main Authors MAG, M, SCHMIDT, R, ENGELS, JW
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 24.11.1992
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
DINUCLEOSIDE-3'-PHOSPHORAMIDATE
PHOSPHOROTHIOATES
STAUDINGER REACTION
SOLID-PHASE SYNTHESIS
ANALOGS
DNA
BONDS
ION
OLIGODEOXYNUCLEOTIDE
OLIGODEOXYRIBONUCLEOTIDES
NUCLEIC-ACIDS
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Summary:A self complementary oligodeoxynucleotide dodecamer containing an achiral bridged 3'-phosphoramidate linkage 3'-NH-P-O-5' has been prepared using the solid phase phosphoramidite procedure. Cleavage of the P-N bond can be accomplished selectively by mild acidolysis.
ISSN:0040-4039
DOI:10.1016/S0040-4039(00)60176-4