A Method for Pyrrole Synthesis through Intramolecular Cyclization of gamma-Alkynyl Oximes Promoted by Sml(2)

• Published in: Synthesis (Stuttgart) Vol. 54; no. 24; pp. 5491 - 5499
• Main Authors: Wang, Yiqiong, Zhang, Lingyu, Zhang, Songlin
• Format: Journal Article
• Language: English
• Published: STUTTGART Thieme Medical Publishers 15.12.2022
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; ORGANIC-SYNTHESIS; ROUTE; TOYOCAMYCIN; DESIGN; ANALOGS; atomic economic; CATALYST; oxime; pyrrole; gamma-alkynyl; Sml; N-centered radical; ESTERS; FUNCTIONAL-GROUPS; DERIVATIVES; EFFICIENT

A new strategy for the synthesis of pyrrole through intramolecular cyclization of gamma-alkynyl oximes promoted by Smt(2) is reported for the first time. In contrast to the prior methods, the selection of oxime instead of oxime ether or ester as substrate makes the synthetic method without accompani...