Metal-free, one-pot synthesis of 2-styrylquinolines via Friedlander annulation and sp(3) C-H activation using 1,3-dimethylurea and L-tartaric acid (3:1) as a deep eutectic solvent

• Published in: New journal of chemistry Vol. 46; no. 4; pp. 1637 - 1642
• Main Authors: Satyanarayana, Neeli, Sathish, Kota, Nagaraju, Sakkani, Pawar, Ravinder, Faizan, Mohmmad, Arumugavel, Murgan, Shirisha, Thangellapally, Kashinath, Dhurke
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 24.01.2022
• Subjects: Chemistry; Chemistry, Multidisciplinary; Physical Sciences; Science & Technology; QUINOLINE; FACILE SYNTHESIS; METHYL AZAARENES; QUINALDINE RED; STYRYLQUINOLINE; CATALYZED DIRECT ALKENYLATION; 2-SUBSTITUTED AZAARENES; DERIVATIVES; FLUORESCENT-PROBE; C(SP)-H FUNCTIONALIZATION

A simple, metal-free protocol is reported for the one-pot synthesis of 2-styrylquinolines using a combination of 1,3-dimethyl urea (1,3-DMU) and L-tartaric acid (LTA) (in a 3 : 1 ratio) as a deep eutectic solvent (DES). The reaction proceeds via Friedlander annulation followed by Knoevenagel condens...