Development of the First Aliphatic F-18-Labeled Tetrazine Suitable for Pretargeted PET Imaging.Expanding the Bioorthogonal Tool Box

• Published in: Journal of medicinal chemistry Vol. 64; no. 20; pp. 15297 - 15312
• Main Authors: Battisti, Umberto M., Bratteby, Klas, Jorgensen, Jesper T., Hvass, Lars, Shalgunov, Vladimir, Mikula, Hannes, Kjaer, Andreas, Herth, Matthias Manfred
• Format: Journal Article
• Language: English
• Published: WASHINGTON Amer Chemical Soc 28.10.2021
• Subjects: Chemistry, Medicinal; Life Sciences & Biomedicine; Pharmacology & Pharmacy; Science & Technology; IN-VIVO CHEMISTRY; STRATEGY; THERANOSTICS; FUTURE; F-18

Pretargeted imaging of nanomedicines have attracted considerable interest because it has the potential to increase imaging contrast while reducing radiation burden to healthy tissue. Currently, the tetrazine ligation is the fastest bioorthogonal reaction for this strategy and, consequently, the stat...